Detecting Release of Bacterial dsDNA into the Host Cytosol Using Fluorescence Microscopy.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7519-8_13
Abstract: Recognition of pathogens by the innate immune system relies on germline-encoded pattern recognition receptors (PRRs) that recognize unique microbial molecules, so-called pathogen-associated molecular patterns (PAMPs). Nucleic acids and their derivatives are one of the most… read more here.
Keywords: bacterial dsdna; microscopy; host; cytosol ... See more keywords
Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2018 at "GeroScience"
DOI: 10.1007/s11357-018-0039-6
Abstract: To investigate the role of increased levels of thioredoxin (Trx) in both the cytosol (Trx1) and mitochondria (Trx2) on aging, we have conducted a study to examine survival and age-related diseases using male mice overexpressing… read more here.
Keywords: txntg txn2tg; c57bl mice; age related; mice ... See more keywords
Cytosolic Crowding Drives the Dynamics of Both Genome and Cytosol in Escherichia coli Challenged with Sub-lethal Antibiotic Treatments
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DOI: 10.1016/j.isci.2020.101560
Abstract: Summary In contrast to their molecular mode of action, the system-level effect of antibiotics on cells is only beginning to be quantified. Molecular crowding is expected to be a relevant global regulator, which we explore… read more here.
Keywords: escherichia coli; sub lethal; crowding drives; cytosolic crowding ... See more keywords
Enhanced Drug Delivery into Cell Cytosol via Glycoprotein H-Derived Peptide Conjugated Nanoemulsions.
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DOI: 10.1021/acsnano.7b03058
Abstract: The key role of nanocarriers in improving the pharmacological properties of commonly used drugs is recognized worldwide. It is also known that in the development of new effective nanocarriers the use of targeting moieties integrated… read more here.
Keywords: cytosol via; drug delivery; cell cytosol; enhanced drug ... See more keywords
Breaking and exiting
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.369.6504.640-a
Abstract: Cell Biology Some bacteria, including Salmonella and Shigella spp., can take up residence within vacuoles inside mammalian host cells. To gain access to the nutrient-rich host cytosol, the internalized bacteria must break out from their… read more here.
Keywords: microscopy; breaking exiting; biology; host ... See more keywords
A human apolipoprotein L with detergent-like activity kills intracellular pathogens
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abf8113
Abstract: Cleansing the cytosol Most human cells, not just those belonging to the immune system, mount protective responses to infection when activated by the immune cytokine interferon-gamma (IFN-γ). How IFN-γ confers this function in nonimmune cells… read more here.
Keywords: microscopy; ifn; host; detergent like ... See more keywords
Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells
Sign Up to like & getrecommendations! Published in 2017 at "BMC Biology"
DOI: 10.1186/s12915-017-0471-6
Abstract: BackgroundPhthiocerol dimycocerosates (PDIM), glycolipids found on the outer surface of virulent members of the Mycobacterium tuberculosis (Mtb) complex, are a major contributing factor to the pathogenesis of Mtb. Myelocytic cells, such as macrophages and dendritic… read more here.
Keywords: cytosol; mtb; lymphatic endothelial; intracellular burden ... See more keywords
On Being the Right Size as an Animal with Plastids
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2017.01402
Abstract: Plastids typically reside in plant or algal cells—with one notable exception. There is one group of multicellular animals, sea slugs in the order Sacoglossa, members of which feed on siphonaceous algae. The slugs sequester the… read more here.
Keywords: animal plastids; size animal; right size; cytosol ... See more keywords