From Stores to Sinks: Structural Mechanisms of Cytosolic Calcium Regulation.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55858-5_10
Abstract: All eukaryotic cells have adapted the use of the calcium ion (Ca2+) as a universal signaling element through the evolution of a toolkit of Ca2+ sensor, buffer and effector proteins. Among these toolkit components, integral… read more here.
Keywords: stores sinks; movement ca2; surface; ca2 ... See more keywords
A nonstructural 2B protein of enterovirus A71 increases cytosolic Ca2+ and induces apoptosis in human neuroblastoma SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of NeuroVirology"
DOI: 10.1007/s13365-019-00824-0
Abstract: Enterovirus A71 (EV-A71) is one of the causative agents causing the hand-foot-mouth disease which associated with fatal neurological complications. Several sporadic outbreaks of EV-A71 infections have been recently reported from Asia-Pacific regions and potentially established… read more here.
Keywords: protein; caspase; cytosolic ca2; a71 ... See more keywords
Cytosolic Ca2+ oversees the MASs production of pyruvate for the mitochondrial market.
Sign Up to like & getrecommendations! Published in 2020 at "Cell calcium"
DOI: 10.1016/j.ceca.2020.102223
Abstract: It is generally accepted that mitochondrial Ca2+ controls the pace of mitochondrial bioenergetics and thus ATP production. Szibor et al. challenge this paradigm, proposing that the balance between ATP consumption and production depends on mitochondrial… read more here.
Keywords: oversees mass; ca2 oversees; production; ca2 ... See more keywords
KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24739-9
Abstract: Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile IP3Rs,… read more here.
Keywords: ca2 signals; krap tethers; ca2 puffs; ca2 ... See more keywords
The human two-pore channel 1 is modulated by cytosolic and luminal calcium
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DOI: 10.1038/srep43900
Abstract: Two-pore channels (TPC) are intracellular endo-lysosomal proteins with only recently emerging roles in organellar signalling and involvement in severe human diseases. Here, we investigated the functional properties of human TPC1 expressed in TPC-free vacuoles from… read more here.
Keywords: pore channel; two pore; human two; ca2 ... See more keywords
Cx32 hemichannel opening by cytosolic Ca2+ is inhibited by the R220X mutation that causes Charcot-Marie-Tooth disease
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx386
Abstract: Mutations of the GJB1 gene encoding connexin 32 (Cx32) cause the X-linked form of Charcot-Marie-Tooth disease (CMTX1), a demyelinating peripheral neuropathy for which there is no cure. A growing body of evidence indicates that ATP… read more here.
Keywords: hemichannel opening; cx32; charcot marie; cytosolic ca2 ... See more keywords
Insight towards the identification of cytosolic Ca2+‐binding sites in ryanodine receptors from skeletal and cardiac muscle
Sign Up to like & getrecommendations! Published in 2017 at "Acta Physiologica"
DOI: 10.1111/apha.12772
Abstract: Ca2+ plays a critical role in several processes involved in skeletal and cardiac muscle contraction. One key step in cardiac excitation–contraction (E–C) coupling is the activation of the cardiac ryanodine receptor (RYR2) by cytosolic Ca2+… read more here.
Keywords: muscle; ca2 binding; skeletal cardiac; binding sites ... See more keywords
High-resolution analysis of the cytosolic Ca2+ events in β cell collectives in situ
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Endocrinology and Metabolism"
DOI: 10.1152/ajpendo.00165.2022
Abstract: The release of peptide hormones is predominantly regulated by a transient increase in cytosolic Ca2+ concentration ([Ca2+]c). To trigger exocytosis, Ca2+ ions enter the cytosol from intracellular Ca2+ stores or from the extracellular space. The… read more here.
Keywords: ca2 events; cell collectives; high resolution; cytosolic ca2 ... See more keywords
Establishment of a NanoBiT-Based Cytosolic Ca2+ Sensor by Optimizing Calmodulin-Binding Motif and Protein Expression Levels
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DOI: 10.14348/molcells.2020.0144
Abstract: Cytosolic Ca2+ levels ([Ca2+]c) change dynamically in response to inducers, repressors, and physiological conditions, and aberrant [Ca2+]c concentration regulation is associated with cancer, heart failure, and diabetes. Therefore, [Ca2+]c is considered as a good indicator… read more here.
Keywords: protein expression; expression levels; calmodulin; expression ... See more keywords
Prostaglandin D2 Induces Ca2+ Sensitization of Contraction without Affecting Cytosolic Ca2+ Level in Bronchial Smooth Muscle
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19103036
Abstract: Prostaglandin D2 (PGD2) is one of the key lipid mediators of allergic airway inflammation, including bronchial asthma. However, the role of PGD2 in the pathogenesis of asthma is not fully understood. In the present study,… read more here.
Keywords: bronchial smooth; contraction; smooth muscle; cytosolic ca2 ... See more keywords
In Vitro Oxidative Stress Threatening Maize Pollen Germination and Cytosolic Ca2+ Can Be Mitigated by Extracts of Emmer Wheatgrass Biofortified with Selenium
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DOI: 10.3390/plants11070859
Abstract: In this work, we studied the effects of in vitro oxidative stress applied by H2O2 to maize pollen germination and cytosolic Ca2+, taken as an experimental model to test the biological activity of extracts of… read more here.
Keywords: oxidative stress; maize pollen; wheatgrass; cytosolic ca2 ... See more keywords