SAMHD1 and the innate immune response to cytosolic DNA during DNA replication.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.09.017
Abstract: Cytosolic DNA of endogenous or exogenous origin is sensed by the cGAS-STING pathway to activate innate immune responses. Besides microbial DNA, this pathway detects self-DNA in the cytoplasm of damaged or abnormal cells and plays… read more here.
Keywords: dna; cytosolic dna; samhd1 innate; innate immune ... See more keywords
TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-02936-3
Abstract: Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) produces the second messenger cGAMP, which… read more here.
Keywords: cgas; production; dna; cytosolic dna ... See more keywords
Identification of a small molecule that primes the type I interferon response to cytosolic DNA
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02776-z
Abstract: The type I interferon response plays a pivotal role in host defense against infectious agents and tumors, and promising therapeutic approaches rely on small molecules designed to boost this system. To identify such compounds, we… read more here.
Keywords: type interferon; response; interferon response; interferon ... See more keywords
cGAS–STING cytosolic DNA sensing pathway is suppressed by JAK2-STAT3 in tumor cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86644-x
Abstract: Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA and subsequent activation of the STING signaling pathway. Here,… read more here.
Keywords: jak2 stat3; dna; tumor cells; cytosolic dna ... See more keywords
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1717190115
Abstract: Significance Necroptosis is a regulated form of necrotic cell death that is important in physiology and human diseases. However, the signaling process leading to eventual cell death in necroptosis remains unclear. We show that PUMA,… read more here.
Keywords: dna sensors; death; dna; puma ... See more keywords
The cytosolic DNA sensor AIM2 promotes Helicobacter‐induced gastric pathology via the inflammasome
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12641
Abstract: Helicobacter pylori (H. pylori) infection can trigger chronic gastric inflammation perpetuated by overactivation of the innate immune system, leading to a cascade of precancerous lesions culminating in gastric cancer. However, key regulators of innate immunity that… read more here.
Keywords: aim2; helicobacter induced; gastric pathology; cytosolic dna ... See more keywords
Identification of Cytosolic DNA Sensor cGAS-STING as Immune-Related Risk Factor in Renal Carcinoma following Pan-Cancer Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/7978042
Abstract: Background The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) plays critical functions in innate immune responses via the production of the second messenger cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), which stimulates the adaptor stimulator of interferon… read more here.
Keywords: sting score; cytosolic dna; cgas sting; cgas ... See more keywords
What Is the Role of the Cytosolic DNA Response in Neurodegeneration?
Sign Up to like & getrecommendations! Published in 2021 at "Neurology"
DOI: 10.1212/wnl.0000000000011944
Abstract: Detection of cytosolic DNA triggers an innate immune response that leads to neuroinflammation. The sources of such DNA include viral or bacterial pathogens as well as nuclear and mitochondrial DNA (mtDNA) released in pathologic conditions.1… read more here.
Keywords: response; dna; role cytosolic; neurodegeneration ... See more keywords
Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1039009
Abstract: Base excision repair (BER) has evolved to maintain the genomic integrity of DNA following endogenous and exogenous agent induced DNA base damage. In contrast, aberrant BER induces genomic instability, promotes malignant transformation and can even… read more here.
Keywords: dna; inflammatory response; cytosolic dna; mediated inflammatory ... See more keywords
Cytosolic DNA sensors and glial responses to endogenous DNA
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1130172
Abstract: Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic… read more here.
Keywords: endogenous dna; dna; sensors glial; dna sensors ... See more keywords
Immune Regulation by Cytosolic DNA Sensors in the Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15072114
Abstract: Simple Summary Cytosolic DNA sensors (CDSs), expressed in various types of immune and tumor cells, recognize double-stranded DNA (dsDNA) in the cytoplasm. These molecules are activated after the dsDNA recognition and initiate a cascade of… read more here.
Keywords: dna; anti tumor; dna sensors; tumor microenvironment ... See more keywords