Articles with "cytosolic dsdna" as a keyword



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IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formation

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Published in 2022 at "Oncoimmunology"

DOI: 10.1080/2162402x.2022.2044103

Abstract: ABSTRACT Stimulator of interferon genes (STING) pathway activation predicts the effectiveness of targeting the PD-1/PD-L1 axis in lung cancer. Active IFN-γ signaling is a common feature in tumors that respond to PD-1/PD-L1 blockade. The connection… read more here.

Keywords: dna damage; sting pathway; ifn; cytosolic dsdna ... See more keywords