Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors.
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DOI: 10.1021/acs.jmedchem.0c01715
Abstract: The cytosolic Hsp90-selective inhibitor TAS-116 has an acceptable safety profile and promising antitumor activity in clinical trials. We examined the binding characteristics of TAS-116 and its analogs to determine the impact of the ligand binding… read more here.
Keywords: potency selectivity; hsp90; cytosolic hsp90; selectivity cytosolic ... See more keywords
Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance
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DOI: 10.3390/biom12091166
Abstract: The heat shock protein 90 (Hsp90) is a molecular chaperone and a key regulator of proteostasis under both physiological and stress conditions. In mammals, there are two cytosolic Hsp90 isoforms: Hsp90α and Hsp90β. These two… read more here.
Keywords: cytosolic hsp90; isoform; specific functions; hsp90 isoform ... See more keywords