Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease.
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DOI: 10.1016/j.cmet.2021.06.013
Abstract: Electron transport chain (ETC) dysfunction or hypoxia causes toxic NADH accumulation. How cells regenerate NAD+ under such conditions remains elusive. Here, integrating bioinformatic analysis and experimental validation, we identify glycerol-3-phosphate (Gro3P) biosynthesis as an endogenous… read more here.
Keywords: gro3p synthesis; biosynthesis; cytosolic nad; glycerol phosphate ... See more keywords