Single domain antibodies for the knockdown of cytosolic and nuclear proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3154
Abstract: Single domain antibodies (sdAbs) from camels or sharks comprise only the variable heavy chain domain. Human sdAbs comprise the variable domain of the heavy chain (VH) or light chain (VL) and can be selected from… read more here.
Keywords: sdabs; single domain; domain antibodies; cytosolic nuclear ... See more keywords
Structure Rigidification Promoted Ultrabright Solvatochromic Fluorescent Probes for Super-Resolution Imaging of Cytosolic and Nuclear Lipid Droplets.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00964
Abstract: Lipid droplets (LDs) containing cytosolic and nuclear LDs have recently received increasing attention because of their diverse biological roles in living systems. However, developing fluorescent probes for super-resolution visualization of these subcellular LDs still remains… read more here.
Keywords: lipid droplets; super resolution; resolution; cytosolic nuclear ... See more keywords
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00830
Abstract: A major obstacle in the development of effective oligonucleotide therapeutics is a lack of understanding about their cytosolic and nuclear penetration. To address this problem, we have applied the chloroalkane penetration assay (CAPA) to oligonucleotide… read more here.
Keywords: quantitative measurement; penetration; nuclear penetration; cytosolic nuclear ... See more keywords
Characterization of the nuclear and cytosolic transcriptomes in human brain tissue reveals new insights into the subcellular distribution of RNA transcripts.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-83541-1
Abstract: Transcriptome analysis has mainly relied on analyzing RNA sequencing data from whole cells, overlooking the impact of subcellular RNA localization and its influence on our understanding of gene function, and interpretation of gene expression signatures… read more here.
Keywords: analysis; rna; human brain; rna transcripts ... See more keywords
Extracellular and intracellular tumor necrosis factor alpha modulates cytosolic and nuclear calcium in human cardiovascular cells 1.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2019-0070
Abstract: Tumor necrosis factor alpha (TNFα) and its type 1 receptor (TNFR1) are implicated in several autoimmune diseases, including rheumatoid arthritis, and are associated with complications at the cardiovascular level. Using human cardiomyocytes, vascular smooth muscle,… read more here.
Keywords: factor alpha; endothelial cells; cardiovascular cells; tumor necrosis ... See more keywords
Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.896472
Abstract: Thymic epithelial cells (TECs) critically participate in T cell maturation and selection for the establishment of immunity to foreign antigens and immune tolerance to self-antigens of T cells. It is well known that many intracellular… read more here.
Keywords: cell; thymic epithelial; dhx9; nuclear sensor ... See more keywords