Cytosolic protein delivery using ultrasound-guided vaporization of perfluorocarbon nano-droplets.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202300018
Abstract: Ultrasound-guided protein delivery is promising for site-specific control of cellular functions in the deep interior of the body in a noninvasive manner. Herein, we propose a method for cytosolic protein delivery based on ultrasound-guided intracellular… read more here.
Keywords: nano droplets; protein delivery; cytosolic protein; ultrasound guided ... See more keywords
Cytosolic Protein Delivery Using Modular Biotin-Streptavidin Assembly of Nanocomposites.
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DOI: 10.1021/acsnano.1c06768
Abstract: Current strategies for the delivery of proteins into cells face general challenges of endosomal entrapment and concomitant degradation of protein cargo. Efficient delivery directly to the cytosol overcomes this obstacle: we report here the use… read more here.
Keywords: biotin streptavidin; delivery; cytosolic protein; protein ... See more keywords
Photoenhanced cytosolic protein delivery based on a photocleavable group-modified dendrimer.
Sign Up to like & getrecommendations! Published in 2021 at "Nanoscale"
DOI: 10.1039/d1nr04430c
Abstract: Numerous recently developed therapies have highlighted the advantages of using proteins as therapeutics. However, in many protein delivery systems, the complicated carrier designs, low loading content, and off-targeting effects have limited their clinical applications. Here… read more here.
Keywords: protein; photoenhanced cytosolic; protein delivery; dendrimer ... See more keywords
It's not just a phase; ubiquitination in cytosolic protein quality control
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200694
Abstract: The accumulation of misfolded proteins is associated with numerous degenerative conditions, cancers and genetic diseases. These pathological imbalances in protein homeostasis (termed proteostasis), result from the improper triage and disposal of damaged and defective proteins… read more here.
Keywords: control; protein quality; cytosolic protein; quality control ... See more keywords
Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006398
Abstract: Key Points A missense mutation in LCP1, an actin-bundling protein, results in severe neutropenia, migration defects, and susceptibility to infection. LCP1 mutation causes actin dysregulation with increased F-actin, G2/M cell cycle arrest, dysplastic cells, and… read more here.
Keywords: lymphocyte cytosolic; protein plastin; i232f mutation; plastin i232f ... See more keywords
Recent Progress of Rational Modified Nanocarriers for Cytosolic Protein Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15061610
Abstract: Therapeutic proteins garnered significant attention in the field of disease treatment. In comparison to small molecule drugs, protein therapies offer distinct advantages, including high potency, specificity, low toxicity, and reduced carcinogenicity, even at minimal concentrations.… read more here.
Keywords: recent progress; protein delivery; progress rational; delivery ... See more keywords