Safe and selective anticancer agents from tetrafluorinated azobenzene‐imidazolium ionic liquids: Synthesis, characterization, and cytotoxic effects
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200085
Abstract: A new series of tetrafluorinated azobenzene‐imidazolium salts is reported. The azobenzene and imidazolium moieties were functionalized with long alkyl chains and connected via a methylene spacer of varying lengths (n = 3–12). They were characterized using FTIR… read more here.
Keywords: cytotoxic; azobenzene imidazolium; ionic liquids; tetrafluorinated azobenzene ... See more keywords
Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid
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DOI: 10.1002/cmdc.201600626
Abstract: A total of 41 new triterpenoids were prepared from allobetulone, methyl betulonate, methyl oleanonate, and oleanonic acid to study their influence on cancer cells. Each 3‐oxotriterpene was brominated at C2 and substituted with thiocyanate; subsequent… read more here.
Keywords: methyl; betulonate methyl; cytotoxic; methyl betulonate ... See more keywords
Nanowire Based Guidance of the Morphology and Cytotoxic Activity of Natural Killer Cells.
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DOI: 10.1002/smll.202007347
Abstract: The cytotoxic activity of natural killer (NK) cells is regulated by many chemical and physical cues, whose integration mechanism is still obscure. Here, a multifunctional platform is engineered for NK cell stimulation, to study the… read more here.
Keywords: cytotoxic; natural killer; activity natural; killer cells ... See more keywords
Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2514-2
Abstract: Quercetin is a flavonoid presenting cytotoxicity against different cancer cell lines. We hypothesized that its core could serve as a scaffold for generating more potent compounds. A quercetin–alanine bioconjugate was synthesized, its cellular internalization was… read more here.
Keywords: cell lines; cytotoxic; cancer cell; quercetin ... See more keywords
Silver(I) complexes with chromone-derived hydrazones: investigation on the antimicrobial and cytotoxic effects
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DOI: 10.1007/s10534-017-0013-2
Abstract: Complexes [Ag(HCrPh)2]NO3·2H2O (1) and [Ag(HCrpClPh)2]NO3 (2) were obtained with 3-formyl-6-methylchromone-phenyl hydrazone (HCrPh, HL1) and 3-formyl-6-methylchromone-para-chloro-phenyl hydrazone (HCrpClPh, HL2). Although the hydrazones were inactive, upon coordination to silver(I) antifungal activity significantly improved against several Candida strains.… read more here.
Keywords: derived hydrazones; cytotoxic; silver complexes; chromone derived ... See more keywords
Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0187-7
Abstract: Trimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a… read more here.
Keywords: cytotoxic; activities trimethoprim; genotoxic activities; assessment vitro ... See more keywords
Molecular Interaction, Antimicrobial, Antioxidant, Cytotoxic and Magnetic Properties of Mn12 Benzoate
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cluster Science"
DOI: 10.1007/s10876-019-01633-5
Abstract: The synthesis, crystal structure, antimicrobial activity, cytotoxic effect on root tip of Allium cepa Linn (A. cepa L.), antioxidant and magnetochemical properties of [Mn12O12(PhCO2)16(CH3OH)4]·3CH3CN (1) cluster and its molecular interaction with Rhodamine B (RhB) are… read more here.
Keywords: cytotoxic; mn12 benzoate; molecular interaction;
Chemotherapeutic dosing implicated by pharmacodynamic modeling of in vitro cytotoxic data: a case study of paclitaxel
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-017-9540-2
Abstract: Conventional maximum tolerated doses (MTD) in chemotherapy are recently challenged by an alternative dosing method with low doses and high dosing frequency (LDHF). Still, it remains unclear which chemotherapies would potentially benefit from LDHF. The… read more here.
Keywords: chemotherapeutic dosing; cytotoxic; model; cytotoxic data ... See more keywords
Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Food Measurement and Characterization"
DOI: 10.1007/s11694-020-00661-4
Abstract: In recent times, there has been a growing interest in the exploration of antioxidants and global trend toward the usage of seaweeds in the food industries. The low molecular weight up to 14 kDa sulfated polysaccharides… read more here.
Keywords: cell line; seaweed pavonica; cytotoxic; brown seaweed ... See more keywords
Synthesis, characterisation, nuclease and cytotoxic activity of phosphate-free and phosphate-containing copper $$4^{\prime }$$4′-(N-methylpyridinium)-$$2{,}2^{\prime }{:}6^{\prime }{,}2^{\prime \prime }$$2,2′:6′,2″ terpyridine complexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-018-1422-7
Abstract: Mononuclear Cu(II) pyridinium terpyridine based compounds, viz., [Cu(q- pytpy)(I)$$(\hbox {CH}_{3}\hbox {COO})](\hbox {I})\cdot (2\hbox {H}_{2}\hbox {O})$$(CH3COO)](I)·(2H2O) (1) and [Cu(dipp)(dippH)(q-pytpy)]$${\cdot }(2\hbox {H}_{2}\hbox {O}$$·(2H2O)(DMF) (2) were isolated by reacting $$\hbox {Cu}(\hbox {OAc})_{2}{\cdot }\hbox {H}_{2}\hbox {O}$$Cu(OAc)2·H2O with $$4^{\prime }$$4′-(N-methylpyridinium)-2,$$2^{\prime… read more here.
Keywords: terpyridine; cytotoxic; hbox hbox; prime prime ... See more keywords
Fruits of Rosa brunonii Lindle: An Ethnomedicinal Plant from Foothills of Himalaya with Antibacterial, Antitumor and Cytotoxic Properties
Sign Up to like & getrecommendations! Published in 2021 at "Arabian Journal for Science and Engineering"
DOI: 10.1007/s13369-021-05581-z
Abstract: Traditional uses of plants are one of the important starting points in search of newer and more effective bioactive drug. Rosa brunonii (plant’s family; Rosaceae) is an ethnomedicinal shrub found in lesser Himalaya region. In… read more here.
Keywords: rosa brunonii; cytotoxic; antitumor; brunonii ... See more keywords