Determination of Cytotoxic Activities Against Melanoma Cells Using Flow Cytometry.
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DOI: 10.1007/978-1-0716-1205-7_8
Abstract: Within the adaptive and innate immune system, effector lymphocytes known as cytotoxic T cells (CTLs) or natural killer (NK) cells play an essential role in host defense against tumor cells and virally infected cells. Here… read more here.
Keywords: melanoma cells; determination cytotoxic; cytotoxic activities; flow cytometry ... See more keywords
Antimicrobial and cytotoxic activities of short carbon chain unsaturated sucrose esters
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DOI: 10.1007/s00044-017-2121-5
Abstract: A library of C3–C5 unsaturated 6-O-sucrose esters have been investigated for their antibacterial, antifungal, and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important… read more here.
Keywords: unsaturated sucrose; sucrose esters; short carbon; cytotoxic activities ... See more keywords
Synthesis and biological evaluation of 3,6-dialkylsubstituted-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles
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DOI: 10.1007/s12039-018-1423-6
Abstract: A series of 3,6-dialkyl-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazole (10) analogues were prepared through multistep synthesis and evaluated them for their antimicrobial and cytotoxic activities. Synthesis of target compounds was carried out using undecenoic acid as starting material, which… read more here.
Keywords: upmu hbox; cytotoxic activities; tested strains; antimicrobial cytotoxic ... See more keywords
Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activities.
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DOI: 10.1016/j.bioorg.2020.103741
Abstract: A phytochemical investigation to obtain bioactive substances as lead compounds or agents for cancer led to the obtainment of six new and two known clerodane diterpenoids from the leaves of Casearia kurzii. Their structures were… read more here.
Keywords: kurzii showing; casearia kurzii; showing cytotoxic; cytotoxic activities ... See more keywords
Vibsane-type diterpenoids from Viburnum odoratissimum and their cytotoxic activities.
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DOI: 10.1016/j.bioorg.2020.104498
Abstract: Seven new diterpenoids (1-7), including five 7-membered ring vibsane-type diterpenoids, vibsanolide A-E (1-5) and a pair of epimers of 14,15,16,17-tetranorvibsane-type diterpenoids possessing bicyclo[4.2.1]nonane moiety, vibsanolide F-G (6-7), together with twelve known analogues (8-19) were isolated… read more here.
Keywords: diterpenoids viburnum; vibsane type; cytotoxic activities; type diterpenoids ... See more keywords
Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
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DOI: 10.1016/j.ejmech.2019.01.038
Abstract: Thirty-six N-arylsulfonyl-3-substituted indoles were designed and synthesized by combining the N-arylsulfonylindoles with aminoguanidine, semicarbazide, and thiosemicarbazide, respectively. Their antibacterial activities were screened, and cytotoxic activities were evaluated. The results showed that aminoguanidines (6) exhibited much… read more here.
Keywords: aminoguanidine semicarbazide; docking studies; cytotoxic activities; semicarbazide thiosemicarbazide ... See more keywords
Cassaine diterpenoids from the seeds of Erythrophleum fordii and their cytotoxic activities.
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DOI: 10.1016/j.fitote.2018.02.028
Abstract: Six new cassaine diterpenoids (1, 3-7), along with three known ones (2, 8-9) were isolated from the seeds of Erythrophleum fordii. Their structures were elucidated by extensive spectroscopic methods and acid hydrolysis. Compound 2 was… read more here.
Keywords: diterpenoids seeds; fordii cytotoxic; cassaine diterpenoids; seeds erythrophleum ... See more keywords
Acylphloroglucinol derivatives from the leaves of Syzygium samarangense and their cytotoxic activities.
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DOI: 10.1016/j.fitote.2018.06.002
Abstract: Samarones A-D (1-4), four new acylphloroglucinol derivatives bearing a C17 alkyl side chain, along with five known analogues (5-9), were isolated from the leaves of Syzygium samarangense. Their structures were characterized on the basis of… read more here.
Keywords: cytotoxic activities; syzygium samarangense; leaves syzygium; acylphloroglucinol derivatives ... See more keywords
Terpenes isolated from Polyalthia simiarum and their cytotoxic activities.
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DOI: 10.1016/j.fitote.2020.104734
Abstract: Two new C31 triterpenes, polysimiaric acid A (1) and B (2) as well as one new clerodane diterpenoid, 16,16-dimethoxy-cleroda-3,13Z-dien-15-oic acid (3), together with six known compounds were isolated from Polyalthia simiarum. Their structures were determined… read more here.
Keywords: polyalthia simiarum; isolated polyalthia; cytotoxic activities; simiarum cytotoxic ... See more keywords
2-Hydroxyanthraquinone substituted cyclotriphosphazenes: Synthesis and cytotoxic activities in cancer cell lines
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DOI: 10.1016/j.ica.2020.120005
Abstract: Abstract Scientists continue to synthesize substances that have cytotoxic effects and examine their properties to overcome cancer for a long time. This study is aimed at preparing novel cyclotriphosphazene derivatives and examining their anti-cancer effects.… read more here.
Keywords: cell lines; cytotoxic activities; cancer cell; cancer ... See more keywords
Synthesis of novel 4′-acylamino modified 21E-benzylidene steroidal derivatives and their cytotoxic activities
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DOI: 10.1016/j.steroids.2017.04.006
Abstract: &NA; A series of 4′‐acylamino modified &Dgr;1,4‐pregnadien‐21E‐benzylidene‐3,20‐dione derivatives (6a–v) was synthesized from the commercially available progesterone (1). These title compounds were evaluated for their toxicity against brine shrimp (Artemia salina) and cytotoxic activities against two… read more here.
Keywords: cytotoxic activities; 21e benzylidene; acylamino modified; modified 21e ... See more keywords