Synthesis of Caerulomycins E and A Analogs for Studying Cytotoxic Activity
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DOI: 10.1002/cmdc.202500594
Abstract: Caerulomycin A, a marine‐derived natural product featuring a bipyridinic core and a substituted oxime functional group, was originally isolated from Streptomyces caeruleus and is known for its antibiotic, antifungal, and cytotoxic properties. In this study,… read more here.
Keywords: caerulomycin; benzyl ether; synthesis; cytotoxic activity ... See more keywords
Synthesis, Cytotoxicity, Apoptotic Activity, Oxidative Stress Inductive Capacity, and Molecular Interactions of Thymol‐Derived Imines
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DOI: 10.1002/jbt.70601
Abstract: Schiff bases (imines) have emerged as promising compounds with significant anticancer potential, owing to their ability to induce cytotoxicity and apoptosis in cancer cells. In this study, a series of thymol‐based imines were synthesized and… read more here.
Keywords: cytotoxic activity; oxidative stress; cytotoxicity; activity ... See more keywords
Aziridine‐Functionalized 1,3,5‐Triazine Derivatives as Promising Anticancer Agents: Synthesis, DFT Study, DNA Binding Investigations and In Vitro Cytotoxic Activity
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DOI: 10.1002/jhet.4908
Abstract: Herein, we report a synthesis and characterization of aziridine‐functionalized 1,3,5‐triazine derivatives. Electronic structure and the most preferable geometry of substances were calculated by DFT method. DNA binding investigations were conducted as part of the biomedicinal… read more here.
Keywords: aziridine functionalized; triazine derivatives; functionalized triazine; cytotoxic activity ... See more keywords
Cytotoxic activity of halogenated sesquiterpenes from Laurencia dendroidea
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DOI: 10.1002/ptr.6052
Abstract: Red algae of the genus Laurencia J. V. Lamouroux are found in tropical and subtropical regions throughout the world and are an extremely rich source of active secondary metabolites with diverse structural features. In the… read more here.
Keywords: halogenated sesquiterpenes; colo 205; activity halogenated; laurencia dendroidea ... See more keywords
Nanowire Based Guidance of the Morphology and Cytotoxic Activity of Natural Killer Cells.
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DOI: 10.1002/smll.202007347
Abstract: The cytotoxic activity of natural killer (NK) cells is regulated by many chemical and physical cues, whose integration mechanism is still obscure. Here, a multifunctional platform is engineered for NK cell stimulation, to study the… read more here.
Keywords: cytotoxic; natural killer; activity natural; killer cells ... See more keywords
Effect of Fibroblast-Like Cells of Mesenchymal Origin of Cytotoxic Activity of Lymphocytes against NK-Sensitive Target Cells
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-017-3658-5
Abstract: We studied immunosuppressive properties of skin fibroblasts and mesenchymal stromal cells against NK cells. In vitro experiments showed that mesenchymal stromal cells isolated from human umbilical cord and human skin fibroblasts can considerably attenuate cytotoxic… read more here.
Keywords: fibroblast like; cells mesenchymal; like cells; activity ... See more keywords
Cytotoxic Activity of Peripheral Blood NK Cells towards Trophoblast Cells during Pregnancy
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DOI: 10.1007/s10517-019-04393-4
Abstract: We evaluated cytotoxic activity of peripheral blood NK cells towards trophoblast cells. NK cells either isolated or in the composition of mononuclear cell fraction, caused death of trophoblast cells. In women with physiological pregnancy, the… read more here.
Keywords: trophoblast cells; activity peripheral; cytotoxic activity;
Study of potent cytotoxic activity of Helleborus cyclophyllus Boiss against a human adenocarcinoma cell line
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DOI: 10.1007/s10616-020-00425-4
Abstract: Helleborus cyclophyllus Boiss is a rhizomatous plant species, with strong allelochemical properties, that has been used since ancient times for its therapeutic properties. In the present study we investigated the ability of an aqueous-soluble fraction… read more here.
Keywords: cyclophyllus boiss; cell line; helleborus cyclophyllus; cell ... See more keywords
Synthesis and cytotoxic activity of isocembrol and its hydroxy derivatives
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DOI: 10.1007/s11172-020-2981-6
Abstract: The synthesis of 2- and 3-hydroxy derivatives of isocembrol was accomplished by the epoxidation of isocembrol with tert-butyl hydroperoxide in the presence of a catalytic amount of VO(acac)2 followed by the epoxide ring opening in… read more here.
Keywords: synthesis cytotoxic; isocembrol; hydroxy derivatives; cytotoxic activity ... See more keywords
New sesquiterpenes from the soft coral Litophyton arboreum
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DOI: 10.1007/s11418-024-01843-w
Abstract: Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were isolated from the soft coral Litophyton arboreum, together with nine known ones, including five sesquiterpenes; 11-hydroxy-8-oxo-β-cyperon (1), alismoxide (4), 5β,8β-epidioxy-11-hydroxy-6-eudesmene (5), chabrolidione B (6), 7-oxo-tri-nor-eudesm-5-en-4β-ol (7),… read more here.
Keywords: new sesquiterpenes; cytotoxic activity; litophyton arboreum; soft coral ... See more keywords
Antimicrobial and cytotoxic activity of extracts from Salvia tebesana Bunge and Salvia sclareopsis Bornm cultivated in Iran
Sign Up to like & getrecommendations! Published in 2019 at "Physiology and Molecular Biology of Plants"
DOI: 10.1007/s12298-019-00652-w
Abstract: Salvia, a member of the Lamiaceae family, represents more than 58 species in Iran. In the present study, antibacterial and cytotoxic activity of extracts obtained from the roots of Salvia tebesana and Salvia sclareopsis were… read more here.
Keywords: salvia tebesana; cytotoxic activity; activity; salvia sclareopsis ... See more keywords