Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.112021
Abstract: A series of novel sulfonamide derivatives bearing pyrrole and pyrrolopyrimidine scaffolds were synthesized and screened as carbonic anhydrase inhibitors. The inhibition activity of the synthesized compounds was evaluated against the cytosolic human carbonic anhydrase isoforms… read more here.
Keywords: cytotoxic agents; sulfonamides act; pyrrolopyrimidine; pyrrolopyrimidine sulfonamides ... See more keywords
Dielectrophoresis-based discrimination of hepatic carcinoma cells following treatment with cytotoxic agents
Sign Up to like & getrecommendations! Published in 2021 at "Engineering Science and Technology, an International Journal"
DOI: 10.1016/j.jestch.2021.04.009
Abstract: Abstract Lack of advancement in detection of abnormal liver cells is a major drawback in hepatocellular carcinoma (HCC) that could results in late diagnosis. This study aims to discriminate the malignant cells from the normal… read more here.
Keywords: carcinoma; treatment; dielectrophoresis; cytotoxic agents ... See more keywords
Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1652292
Abstract: Abstract The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria… read more here.
Keywords: anti inflammatory; agents xylaria; swuf09 fungus; cytotoxic agents ... See more keywords
Cytotoxic Anticancer Agents
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz333
Abstract: Abstract While molecularly targeted drugs and immune checkpoint inhibitors are thriving cancer drugs, cytotoxic anticancer agents are still the basis for treatment of a lot of advanced malignancies. A combination of cytotoxic agents with an… read more here.
Keywords: immune checkpoint; cytotoxic anticancer; cytotoxic agents; anticancer agents ... See more keywords
The Era of the Hepatic Oncologist
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DOI: 10.1159/000508342
Abstract: Traditional phase 1 trials for the development of cytotoxic agents are conducted in order to identify the ideal dose for later phase trials, where the maximum tolerated dose (MTD) is a critical component. The MTD… read more here.
Keywords: era; cytotoxic agents; phase trials; cancer ... See more keywords
Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
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DOI: 10.1186/s13065-017-0338-5
Abstract: A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds were characterized using spectroscopic methods mainly including 1H… read more here.
Keywords: potential cytotoxic; cytotoxic; nicotinamide based; cytotoxic agents ... See more keywords
KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14929
Abstract: KRAS is the most commonly mutated oncogene, frequently associated with some of the deadliest forms of cancer. However, the need for potent and specific KRAS inhibitors remains unmet. Here, we evaluated the effects of selected… read more here.
Keywords: cells cytotoxic; suppression; cytotoxic agents; sensitivity ... See more keywords
Molecular Delivery of Cytotoxic Agents via Integrin Activation
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DOI: 10.3390/cancers13020299
Abstract: Simple Summary Chemotherapy constituted a cornerstone in cancer treatment, but it suffers from non-selective drug cytotoxicity; an active drug targeting exerted by covalent conjugates between antitumor agents and some integrin ligands should have a more… read more here.
Keywords: cytotoxic; molecular delivery; covalent conjugates; cytotoxic agents ... See more keywords
Radiobiological Characterization of Canine Malignant Melanoma Cell Lines with Different Types of Ionizing Radiation and Efficacy Evaluation with Cytotoxic Agents
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20040841
Abstract: Canine malignant melanoma (CMM) is a locally and systemically aggressive cancer that shares many biological and clinical characteristics with human mucosal melanoma. Hypofractionated radiation protocols have been used to treat CMM but little is known… read more here.
Keywords: melanoma; cell lines; cytotoxic agents; cell ... See more keywords
Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179688
Abstract: The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying formaldehyde and piperidine, but a second paraformaldehyde molecule was incorporated… read more here.
Keywords: synthesis hydroxyquinolines; synthesis; hydroxyquinolines potential; cytotoxic agents ... See more keywords
Host-Derived Cytotoxic Agents in Chronic Inflammation and Disease Progression
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24033016
Abstract: At inflammatory sites, cytotoxic agents are released and generated from invading immune cells and damaged tissue cells. The further fate of the inflammation highly depends on the presence of antagonizing principles that are able to… read more here.
Keywords: inflammation; agents chronic; derived cytotoxic; cytotoxic agents ... See more keywords