Cytotoxic and anticancer properties of new ruthenium polypyridyl complexes with different lipophilicities.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2018.01.003
Abstract: Three ruthenium complexes containing a bidentate piq ligand, [(piq)Ru(bpy)2]2+ (1), [(piq)Ru(phen)2]2+ (2), and [(piq)Ru(DIP)2]2+ (3) (piq = phenylisoquinolinate, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, DIP = 4,7-diphenyl-1,10-phenanthroline), were prepared. The DNA binding properties of complexes 1-3 to double-stranded DNA were studied. The binding… read more here.
Keywords: ruthenium; cytotoxic anticancer; dna; anticancer properties ... See more keywords
Cytotoxic Anticancer Agents
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz333
Abstract: Abstract While molecularly targeted drugs and immune checkpoint inhibitors are thriving cancer drugs, cytotoxic anticancer agents are still the basis for treatment of a lot of advanced malignancies. A combination of cytotoxic agents with an… read more here.
Keywords: immune checkpoint; cytotoxic anticancer; cytotoxic agents; anticancer agents ... See more keywords
Efficacy and safety of nanoparticle albumin-bound paclitaxel monotherapy as second-line therapy of cytotoxic anticancer drugs in patients with advanced non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000009320
Abstract: Background: Nanoparticle albumin-bound paclitaxel (nab-PTX), which avoids toxicities associated with a vehicle used in solvent-based PTX, has already shown safety and efficacy in patients with non-small cell lung cancer (NSCLC). Methods: A phase II study… read more here.
Keywords: nab ptx; cytotoxic anticancer; safety; efficacy ... See more keywords
Abstract 5027: Exome sequencing of cancer-related genes to identify genetic markers for sensitivity to cytotoxic anticancer drugs
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5027
Abstract: Although the progress in moving from a one-size-fits-all cytotoxic approach to personalized molecular medicine, majority of the patients with cancer receive chemotherapy with cytotoxic anticancer drugs. Exome sequencing of 409 cancer related genes was conducted… read more here.
Keywords: exome sequencing; cytotoxic anticancer; sensitivity; anticancer drugs ... See more keywords
Pretreatment neutrophil-to-lymphocyte ratio predicts treatment efficacy and prognosis of cytotoxic anticancer drugs, molecular targeted drugs, and immune checkpoint inhibitors in patients with advanced non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Translational lung cancer research"
DOI: 10.21037/tlcr-20-777
Abstract: Background Neutrophil-to-lymphocyte ratio (NLR) has recently attracted attention as a prognostic predictor in patients with non-small cell lung cancer (NSCLC) who receive immune checkpoint inhibitors (ICIs). However, the utility of NLR in relation to cytotoxic… read more here.
Keywords: cytotoxic anticancer; treatment; molecular targeted; anticancer drugs ... See more keywords
Constitutive Expression of a Cytotoxic Anticancer Protein in Tumor-Colonizing Bacteria
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15051486
Abstract: Simple Summary This study examined the biodistribution of Escherichia coli and an attenuated strain of Salmonella enterica serovar Gallinarum with defective ppGpp synthesis after injection into tumor-bearing mice through the tail vein. Bacteria targeting tumor… read more here.
Keywords: gallinarum; tumor; cytotoxic anticancer; expression cytotoxic ... See more keywords
Antibacterial, Antihemolytic, Cytotoxic, Anticancer, and Antileishmanial Effects of Ajuga bracteosa Transgenic Plants
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DOI: 10.3390/plants10091894
Abstract: Herbal and traditional medicines can play a pivotal role in combating cancer and neglected tropical diseases. Ajuga bracteosa, family Lamiaceae, is an important medicinal plant. The genetic transformation of A. bracteosa with rol genes of… read more here.
Keywords: cytotoxic anticancer; ajuga bracteosa; antibacterial antihemolytic; antihemolytic cytotoxic ... See more keywords