Cytotoxic CD4+ T Cells in Bladder Cancer-A New License to Kill.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.06.013
Abstract: CD4+ T cells with cytotoxic capability are increasingly recognized as potentially key actors in anti-tumor immunity. A new report in Cell elucidates the presence and potential role of a population of cytotoxic CD4+ T cells in bladder… read more here.
Keywords: bladder cancer; cd4 cells; cytotoxic cd4; cells bladder ... See more keywords
Characterization of CD4+ T cell-mediated cytotoxicity in patients with multiple myeloma.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.02.009
Abstract: Multiple myeloma (MM) is an incurable cancer characterized by the development of malignant plasma cells. The CD8 T cell-mediated cytotoxicity is considered a major player in antitumor immunity, but in MM patients, the CD8 T… read more here.
Keywords: cd4 cells; cell mediated; cytotoxic cd4; mediated cytotoxicity ... See more keywords
T and B lymphocytes in fibrosis and systemic sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Rheumatology"
DOI: 10.1097/bor.0000000000000644
Abstract: PURPOSE OF REVIEW To summarize recent advances in the understanding of the pathogenesis of autoimmune fibrotic diseases. These diseases include IgG4-related disease, systemic sclerosis and lupus nephritis. RECENT FINDINGS Recent studies indicate that a poorly… read more here.
Keywords: cd4 cells; lymphocytes fibrosis; sclerosis; cytotoxic cd4 ... See more keywords
Cytotoxic CD4+ Cells in Chronic Lymphocytic Leukaemia: An Extended Immunophenotypic Analysis Examining Their Association with Cytomegalovirus Serostatus and Similarities with Cytotoxic CD8+ Cells
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-116798
Abstract: Introduction: CD4+ T lymphocytes play a fundamental role in the adaptive immune system and traditionally their principle function has been seen as one of a 'helper' cell, interacting with and activating fellow immune cells to… read more here.
Keywords: cd4 ctls; cytotoxic cd4; cd4 cells; cd4 ... See more keywords
Fighting Viral Infections and Virus-Driven Tumors with Cytotoxic CD4+ T Cells
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00197
Abstract: CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion,… read more here.
Keywords: virus driven; cd4 cells; driven tumors; cytotoxic cd4 ... See more keywords
Diminished Peripheral CD29hi Cytotoxic CD4+ T Cells Are Associated With Deleterious Effects During SIV Infection
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.734871
Abstract: Cytotoxic CD4+ T cells (CD4+ CTLs) limit HIV pathogenesis, as evidenced in elite controllers (a subset of individuals who suppress the virus without the need for therapy). CD4+ CTLs have also been shown to kill… read more here.
Keywords: cd4 cells; cytotoxic cd4; cd29hi; cd4 ctls ... See more keywords
The Era of Cytotoxic CD4 T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.867189
Abstract: In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three decades, our understanding of… read more here.
Keywords: cell; cytotoxic cd4; cd4 cells; cd4 ... See more keywords
When Helpers Go Above and Beyond: Development and Characterization of Cytotoxic CD4+ T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.951900
Abstract: Once regarded as an experimental artefact, cytotoxic CD4+ T cells (CD4 CTL) are presently recognized as a biologically relevant T cell subset with important functions in anti-viral, anti-tumor, and autoimmune responses. Despite the potentially large… read more here.
Keywords: cd4 cells; cytotoxic cd4; cd4 ctl; cd4 ... See more keywords
Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.977117
Abstract: Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune… read more here.
Keywords: cell; cytotoxic cd4; cd4 cells; cd4 ... See more keywords