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   Articles with "cytotoxic cell" as a keyword



Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

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recommendations! Published in 2024 at "ACS Central Science"

DOI: 10.1021/acscentsci.3c01544

Abstract: Antigen processing is critical for therapeutic vaccines to generate epitopes for priming cytotoxic T cell responses against cancer and pathogens, but insufficient processing often limits the quantity of epitopes released. We address this challenge using… read more here.

Keywords: cytotoxic cell; proteasomal degradation; cytotoxic; machine learning ... See more keywords

Abstract LB-B11: Myeloid p38 MAPK promotes tumorigenesis by suppressing cytotoxic T cell recruitment

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recommendations! Published in 2019 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.targ-19-lb-b11

Abstract: The last decade has seen explosive progress in understanding how tumor-associated macrophages (TAM) contribute to the development, metastasis, and therapy resistance of cancer. TAM and their molecular components are investigated as targets for cancer therapy.… read more here.

Keywords: expression; p38; cancer; cell recruitment ... See more keywords

T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy.

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recommendations! Published in 2017 at "JCI insight"

DOI: 10.1172/jci.insight.96173

Abstract: In the course of modeling the naturally occurring tumor immunity seen in patients with paraneoplastic cerebellar degeneration (PCD), we discovered an unexpectedly high threshold for breaking CD8+ cytotoxic T cell (CTL) tolerance to the PCD… read more here.

Keywords: cells presenting; presenting viral; cytotoxic cell; flu ... See more keywords

High mesothelin expression is associated with low cytotoxic T cell infiltration in pancreatic cancer

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1651687

Abstract: Objectives Mesothelin (MSLN) is a cell-surface glycoprotein overexpressed in the majority of pancreatic ductal adenocarcinoma (PDAC) cases and represents a promising immunotherapeutic target. Despite studies and clinical trials investigating MSLN-targeted immunotherapies, its biological role in… read more here.

Keywords: cytotoxic cell; cell; msln expression; cell infiltration ... See more keywords

Cytotoxic T-Cell-Based Vaccine against SARS-CoV-2: A Hybrid Immunoinformatic Approach

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recommendations! Published in 2022 at "Vaccines"

DOI: 10.3390/vaccines10020218

Abstract: This paper presents an alternative vaccination platform that provides long-term cellular immune protection mediated by cytotoxic T-cells. The immune response via cellular immunity creates superior resistance to viral mutations, which are currently the greatest threat… read more here.

Keywords: class; class class; cell based; cytotoxic cell ... See more keywords