Curcumin restores the engraftment capacity of aged hematopoietic stem cells and also reduces PD‐1 expression on cytotoxic T cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3180
Abstract: Aging affects the functionality of hematopoietic stem cells (HSCs), and therefore, aged individuals are not preferred as donors in HSC transplantation. Such elimination leads to the restriction of donor cohort. Several efforts are being done… read more here.
Keywords: engraftment capacity; medicine; cytotoxic cells; expression ... See more keywords
Follicular helper and follicular cytotoxic T cells in primary Sjögren’s Syndrome: clues for an abnormal antiviral response as a pathogenic mechanism
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Medicine"
DOI: 10.1080/07853890.2018.1561890
Abstract: Introduction: In chronic viral infections, T follicular helper (Tfh) cells are crucial to sustain CD8 cytotoxic T cells in face of the persistence of viral antigens. Moreover, the usual Th1 profile that is associated with… read more here.
Keywords: cytotoxic cells; pss; disease; pss patients ... See more keywords
Regulatory T cells and cytotoxic T cells close to the epithelial–stromal interface are associated with a favorable prognosis
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1746149
Abstract: ABSTRACT Cytotoxic T cells and regulatory T cells play a crucial role in the outcome of cancer patients. Besides the density of these cells, it was shown recently that the spatial distribution is equally important.… read more here.
Keywords: cytotoxic cells; prognosis; stromal interface; epithelial stromal ... See more keywords
1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003477
Abstract: Background Epidemiological surveys have revealed that low serum vitamin D level was correlated with increased risk of tumors. Dysfunctional T cells in patients with tumor are characterized as exhausted with high levels of immune checkpoint… read more here.
Keywords: cell; cytotoxic cells; vitamin; expression ... See more keywords
Abstract LB-108: Generation of off-the-shelf TCR-less CAR-targeted cytotoxic T cells from renewable pluripotent cells for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1158/1538-7445.am2018-lb-108
Abstract: Genetically engineered T cells are at the vanguard of an emerging wave of scientific breakthrough focused on harnessing the power of the immune system to treat cancer and other immune disorders. Perhaps the most dramatic… read more here.
Keywords: cytotoxic cells; shelf; cancer; cell ... See more keywords
Abstract 4107: Cytotoxic T cells armed with IL-4 receptor-targeting and PD-L1-blocking peptides inhibits lung tumor growth
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4107
Abstract: Tumor homing of adoptively transferred cytotoxic T cells (CTLs) to solid tumors is still inefficient. In addition, CTLs that arrive at tumor tissues meet the immune-suppressive tumor microenvironment. To reduce these limitations in adoptive T-cell… read more here.
Keywords: tumor growth; ctls; cytotoxic cells; lung tumor ... See more keywords
Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-19-0483
Abstract: Tumor cells evade NK-cell–mediated immunity by proteolytic shedding of the activating MICA/B ligands. Use of a MICA/B antibody inhibits MICA/B proteolytic shedding, leading to NK-cell responses against tumor cells resistant to cytotoxic T cells. Resistance… read more here.
Keywords: cytotoxic cells; mica; cell mediated; resistant cytotoxic ... See more keywords
Engineered FVIII-expressing cytotoxic T cells target and kill FVIII-specific B cells in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2018018556
Abstract: Hemophilia A is an X-linked bleeding disorder caused by mutations in the factor VIII (FVIII) gene (F8). Treatment with recombinant or plasma-derived FVIII replacement therapy is standard therapy. A major problem in treating hemophilia A… read more here.
Keywords: vitro vivo; cytotoxic cells; fviii; specific cells ... See more keywords
The Expanding Arsenal of Cytotoxic T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.883010
Abstract: Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where… read more here.
Keywords: expanding arsenal; cytotoxic cells; cytotoxic; antigen ... See more keywords
The effect of SMAD4 on the prognosis and immune response in hypopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1139203
Abstract: Objectives In malignant tumors, elevated infiltration of intratumoral CD8+ cytotoxic T cells predicts a beneficial prognosis, whereas high levels of CD15+ neutrophils in peritumor tissues indicate poor prognosis. It is unclear how SMAD4, which promotes… read more here.
Keywords: prognosis; cd15 neutrophils; cd8 cytotoxic; cytotoxic ... See more keywords
Combination Biomarker of Immune Checkpoints Predict Prognosis of Urothelial Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines10010008
Abstract: In contrast to Western counties, the incidence of urothelial carcinoma (UC) remains mar-edly elevated in Taiwan. Regulatory T cells (Tregs) play a crucial role in limiting immune responses within the tumor microenvironment. To elucidate the… read more here.
Keywords: immune checkpoints; prognosis; combination biomarker; urothelial carcinoma ... See more keywords