New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.10.037
Abstract: Carbonic anhydrase IX (CAIX) is a hypoxia-regulated and tumor-specific protein that maintains the pH balance of cells. Targeting CAIX might be a valuable approach for specific delivery of cytotoxic drugs, thereby reducing normal tissue side-effects.… read more here.
Keywords: dual target; caix expressing; target; cytotoxic drugs ... See more keywords
Apatinib inhibits tumour progression and promotes antitumour efficacy of cytotoxic drugs in oesophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17209
Abstract: Apatinib, a highly selective inhibitor of vascular endothelial growth factor receptor‐2 (VEGFR‐2), inhibits the angiogenesis of tumours. The function and mechanism of apatinib in oesophageal squamous cell carcinoma (ESCC) remain unknown. In present study, we… read more here.
Keywords: cell carcinoma; cell; cytotoxic drugs; oesophageal squamous ... See more keywords
Differential Response to Cytotoxic Drugs Explains the Dynamics of Leukemic Cell Death: Insights from Experiments and Mathematical Modeling
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DOI: 10.3390/sym14061269
Abstract: This study presents a framework whereby cancer chemotherapy could be improved through collaboration between mathematicians and experimentalists. Following on from our recently published model, we use A20 murine leukemic cells transfected with monomeric red fluorescent… read more here.
Keywords: cytotoxic drugs; differential response; response cytotoxic; drugs explains ... See more keywords