Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000066
Abstract: A previously designed and developed 12‐step total synthesis that includes [1,1′‐biphenyl]‐2‐amine and carbazole intermediates and that ultimately produces the carbazole alkaloid carbazomycin G was exploited as a screening compound library with the goal of identifying… read more here.
Keywords: total synthesis; leads cytotoxic; cytotoxic effect; hit leads ... See more keywords
Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology"
DOI: 10.1002/tox.24308
Abstract: Plants provide a wide array of compounds that can be explored for potential anticancer properties. Siphonochilone, a furanoterpene that represents one of the main components of the African plant Siphonochilus aethiopicus, shows numerous health benefits.… read more here.
Keywords: cancer; siphonochilone; cytotoxic effect; cancer cell ... See more keywords
Cytotoxic effect of co-expression of human hepatitis A virus 3C protease and bifunctional suicide protein FCU1 genes in a bicistronic vector
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology Reports"
DOI: 10.1007/s11033-017-4113-4
Abstract: Recent reports on various cancer models demonstrate a great potential of cytosine deaminase/5-fluorocytosine suicide system in cancer therapy. However, this approach has limited success and its application to patients has not reached the desirable clinical… read more here.
Keywords: genes bicistronic; cytotoxic effect; fcu1; effect ... See more keywords
Isobutyrylshikonin has a potentially stronger cytotoxic effect in oral cancer cells than its analogue shikonin in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104774
Abstract: OBJECTIVES The aim of the present study was to identify the anticancer effects and the mechanisms of action of shikonin and its analogue isobutyrylshikonin in oral squamous carcinoma cells. DESIGNS The cytotoxic effects of isobutyrylshikonin… read more here.
Keywords: oral cancer; cytotoxic effect; isobutyrylshikonin shikonin; shikonin ... See more keywords
In vitro antioxidant assay guided ex vivo investigation of cytotoxic effect of phytosomes assimilating taxifolin rich fraction of Cedrus deodara bark extract on human breast cancer cell lines (MCF7)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102486
Abstract: Abstract Objective Characterization, in vitro evaluation of antioxidant activity and ex vivo investigation of cytotoxic effect of phytosomes assimilating ethyl acetate fraction fractionated from hydro alcoholic extract of Cedrus deodara bark. Method Solvent fractions of… read more here.
Keywords: investigation cytotoxic; investigation; ethyl acetate; fraction ... See more keywords
Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2017.12.005
Abstract: Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of… read more here.
Keywords: effect; canina extract; cytotoxic effect; rosa ... See more keywords
Chemical composition, cytotoxic effect and antimicrobial activity of Stachys koelzii Rech.f. essential oil against periodontal pathogen Prevotella intermedia.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.08.010
Abstract: Prevotella intermedia is associated with periodontal diseases and endodontic infections. Periodontitis can be suppressed by utilizing the antiseptics, which target the infectious bacteria. The member of Stachys sp. has been used traditionally in the form… read more here.
Keywords: essential oil; prevotella intermedia; cytotoxic effect; chemical composition ... See more keywords
The cytotoxic effect of spiroflavanone derivatives, their binding ability to human serum albumin (HSA) and a DFT study on the mechanism of their synthesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.02.037
Abstract: Abstract This paper examines the cytotoxic effect of nine compounds with spiropyrazoline structures, and determines the reaction mechanism between diazomethane and selected benzylideneflavanones, their lipophilicity, and their binding ability to human serum albumin. The cytotoxic… read more here.
Keywords: human serum; cytotoxic effect; serum albumin;
Binuclear Cu(II) complex based on N-acetylanthranilic acid induces significant cytotoxic effect on three cancer cell lines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131634
Abstract: Abstract This paper presents theisolation of single crystals of an anionic Cu(II) complex (NH4)(NHEt3)[Cu2(L)4Cl2]{HL = N-acetylanthranilic acid and NEt3= triethylamine}. The analyses revealed the complex packing in the triclinic "P-1" space group in addition to its dimeric… read more here.
Keywords: cancer; acetylanthranilic acid; significant cytotoxic; cytotoxic effect ... See more keywords
A Lactoferricin B/Buforin Chimeric Peptide Causes a Rapid, Selective, Prolonged Cytotoxic Effect and Induces Apoptosis in HPV18-Positive Cervical Cancer Cells
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c05953
Abstract: This study focuses on the chimeric peptide KKWQWK-Ahx-RLLRRLLR and its interaction with cancer cells, specifically HPV18-positive cervical cancer HeLa and Ca Ski cells. The main objective of this study was to understand the mode of… read more here.
Keywords: cancer; cancer cells; cervical cancer; chimera ... See more keywords
Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology research"
DOI: 10.1039/c9tx00240e
Abstract: Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO2) towards cancer cells… read more here.
Keywords: hepatocellular carcinoma; nano sio2; cytotoxic effect; sio2 ... See more keywords