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Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000066
Abstract: A previously designed and developed 12‐step total synthesis that includes [1,1′‐biphenyl]‐2‐amine and carbazole intermediates and that ultimately produces the carbazole alkaloid carbazomycin G was exploited as a screening compound library with the goal of identifying…
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Keywords:
total synthesis;
leads cytotoxic;
cytotoxic effect;
hit leads ... See more keywords
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Published in 2017 at "Molecular Biology Reports"
DOI: 10.1007/s11033-017-4113-4
Abstract: Recent reports on various cancer models demonstrate a great potential of cytosine deaminase/5-fluorocytosine suicide system in cancer therapy. However, this approach has limited success and its application to patients has not reached the desirable clinical…
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Keywords:
genes bicistronic;
cytotoxic effect;
fcu1;
effect ... See more keywords
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Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104774
Abstract: OBJECTIVES The aim of the present study was to identify the anticancer effects and the mechanisms of action of shikonin and its analogue isobutyrylshikonin in oral squamous carcinoma cells. DESIGNS The cytotoxic effects of isobutyrylshikonin…
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Keywords:
oral cancer;
cytotoxic effect;
isobutyrylshikonin shikonin;
shikonin ... See more keywords
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Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102486
Abstract: Abstract Objective Characterization, in vitro evaluation of antioxidant activity and ex vivo investigation of cytotoxic effect of phytosomes assimilating ethyl acetate fraction fractionated from hydro alcoholic extract of Cedrus deodara bark. Method Solvent fractions of…
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Keywords:
investigation cytotoxic;
investigation;
ethyl acetate;
fraction ... See more keywords
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Published in 2018 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2017.12.005
Abstract: Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of…
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Keywords:
effect;
canina extract;
cytotoxic effect;
rosa ... See more keywords
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Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.08.010
Abstract: Prevotella intermedia is associated with periodontal diseases and endodontic infections. Periodontitis can be suppressed by utilizing the antiseptics, which target the infectious bacteria. The member of Stachys sp. has been used traditionally in the form…
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Keywords:
essential oil;
prevotella intermedia;
cytotoxic effect;
chemical composition ... See more keywords
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Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.02.037
Abstract: Abstract This paper examines the cytotoxic effect of nine compounds with spiropyrazoline structures, and determines the reaction mechanism between diazomethane and selected benzylideneflavanones, their lipophilicity, and their binding ability to human serum albumin. The cytotoxic…
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Keywords:
human serum;
cytotoxic effect;
serum albumin;
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Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131634
Abstract: Abstract This paper presents theisolation of single crystals of an anionic Cu(II) complex (NH4)(NHEt3)[Cu2(L)4Cl2]{HL = N-acetylanthranilic acid and NEt3= triethylamine}. The analyses revealed the complex packing in the triclinic "P-1" space group in addition to its dimeric…
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Keywords:
cancer;
acetylanthranilic acid;
significant cytotoxic;
cytotoxic effect ... See more keywords
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Published in 2019 at "Toxicology research"
DOI: 10.1039/c9tx00240e
Abstract: Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern. Cytotoxicity of silica nanoparticles (Nano-SiO2) towards cancer cells…
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Keywords:
hepatocellular carcinoma;
nano sio2;
cytotoxic effect;
sio2 ... See more keywords
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Published in 2021 at "IET nanobiotechnology"
DOI: 10.1049/nbt2.12057
Abstract: Graphene-based nanomaterials are gaining importance in biomedicine because of their large surface areas, solubility, and biocompatibility. Green synthesis is the most economical method for application, as it is rapid and sustainable. Biofunctionalized reduced graphene oxide…
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Keywords:
graphene oxide;
mcf cells;
cytotoxic effect;
mcf ... See more keywords
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Published in 2022 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2022.2109046
Abstract: Cervical cancer ranks fourth in incidence among women worldwide. Cisplatin is currently the first-line drug of treatment for cervical cancer; however, it causes serious adverse effects. Therefore, it is crucial to explore natural products for…
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Keywords:
cervical cancer;
prosopis laevigata;
cytotoxic effect;
cancer ... See more keywords