Synthesis and cytotoxic evaluation of malachite green derived oleanolic and ursolic acid piperazineamides
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DOI: 10.1007/s00044-020-02536-1
Abstract: The coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic acid with meta or para substituted carboxylated malachite green analogs gave conjugates 10 , 11 , 15 , and 16 that were cytotoxic for… read more here.
Keywords: ursolic acid; malachite green; cytotoxic evaluation; synthesis cytotoxic ... See more keywords
Isolation, modification and cytotoxic evaluation of stilbenoids from Acanthopanax leucorrhizus.
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DOI: 10.1016/j.fitote.2017.11.007
Abstract: Twenty natural stilbenoids (1-20), including seven new stilbenoids (2, 4-7, 19, 20) and thirteen known stilbenoids (1, 3, 8-18), were isolated from the stem barks of Acanthopanax leucorrhizus, and six modified stilbenoid derivatives (1a, 2a,… read more here.
Keywords: acanthopanax leucorrhizus; cytotoxic evaluation; modification cytotoxic; isolation modification ... See more keywords
14-Residue peptaibol velutibol A from Trichoderma velutinum: its structural and cytotoxic evaluation
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DOI: 10.1039/d0ra05780k
Abstract: Velutibol A (1), a new 14-residue peptaibol was isolated from the Himalayan cold habitat fungus Trichoderma velutinum. The structural characterization was carried out by 1D and 2D NMR studies, and tandem mass studies, and Marfey's… read more here.
Keywords: velutibol; cytotoxic evaluation; trichoderma velutinum; velutinum structural ... See more keywords
Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2166936
Abstract: Abstract Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages.… read more here.
Keywords: thiazole derivatives; bis thiazole; pim1; cytotoxic evaluation ... See more keywords
Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemistry"
DOI: 10.1155/2018/3626824
Abstract: A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl afforded diazonium… read more here.
Keywords: diazene; evaluation newly; characterization cytotoxic; cytotoxic evaluation ... See more keywords
Cytotoxic Evaluation of the New Composite Resin through an Artificial Pulp Chamber
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/5100816
Abstract: The aim of this study was to analyse the cytocompatibility of Surefil One (SuO) with respect to the release of monomers from the material. The following reference materials were chosen: SDR Flow Plus (SDR, Dentsply… read more here.
Keywords: cytotoxic evaluation; evaluation new; artificial pulp; pulp chamber ... See more keywords
Synthesis and Cytotoxic Evaluation of 3-Methylidenechroman-4-ones
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DOI: 10.3390/molecules24101868
Abstract: In the search for new anticancer agents, a library of variously substituted 3-methylidenechroman-4-ones was synthesized using Horner–Wadsworth–Emmons methodology. Acylation of diethyl methylphosphonate with selected ethyl salicylates furnished 3-diethoxyphosphorylchromen-4-ones which were next used as Michael acceptors… read more here.
Keywords: methodology; methylidenechroman ones; evaluation methylidenechroman; cytotoxic evaluation ... See more keywords
Cytotoxic Evaluation and Determination of Organic and Inorganic Eluates from Restorative Materials
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DOI: 10.3390/molecules26164912
Abstract: Over the last years, diverse commercial resin-based composites have dominated as dental filling materials. The purpose of the present study was to determine organic and inorganic eluates from five restorative materials using GC/MS and ICP–OES… read more here.
Keywords: organic inorganic; bioactive restorative; restorative materials; evaluation determination ... See more keywords
Synthesis and cytotoxic evaluation of some new 3-(2-(2-phenylthiazol-4-yl) ethyl)-quinazolin-4(3H) one derivatives with potential anticancer effects
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DOI: 10.4103/1735-5362.212046
Abstract: Quinazolinones are a group of heterocyclic compounds that have important biological activities such as cytotoxicity, anti-bacterial, and anti-fungal effects. Thiazole-containing compounds have also many biological effects including antitumor, antibacterial, anti-inflammatory, and analgesic activities. Due to… read more here.
Keywords: cytotoxic; evaluation new; cytotoxic evaluation; synthesis cytotoxic ... See more keywords
Synthesis and cytotoxic evaluation of some novel quinoxalinedione diarylamide sorafenib analogues
Sign Up to like & getrecommendations! Published in 2018 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.223802
Abstract: A series of novel sorafenib analogues containing a quinoxalinedione ring and amide linker were synthesized. A total of 9 novel compounds in 6 synthetic steps were synthesized. Briefly, the amino group of p-aminophenol was first… read more here.
Keywords: sorafenib analogues; evaluation novel; quinoxalinedione; cytotoxic evaluation ... See more keywords
Synthesis and cytotoxic evaluation of novel quinazolinone derivatives as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2018 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.236838
Abstract: Nitrogen-rich heterocyclic compounds represent a unique class of chemicals with especial properties and have been modified to design novel pharmaceutically active compounds. In this study, a series of novel quinazolinone derivatives with substituted quinoxalindione were… read more here.
Keywords: quinazolinone derivatives; novel quinazolinone; cell lines; cytotoxic evaluation ... See more keywords