TLR1/2 Specific Small‐Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201802042
Abstract: Abstract Toll‐like receptor 2 (TLR2) expressed on antigen presenting cells evokes a series of critical cytokines, which favor the development of tumor‐specific cytotoxic T lymphocytes (CTLs). Therefore, TLR2 represents an attractive cancer immunotherapeutic target. Here,… read more here.
Keywords: cytotoxic lymphocytes; small molecule; molecule agonist;
Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model
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DOI: 10.1016/j.isci.2020.100998
Abstract: Summary Current adoptive T cell therapies conducted in an autologous setting are costly, time consuming, and depend on the quality of the patient's T cells. To address these issues, we developed a strategy in which… read more here.
Keywords: xenograft; therapeutic efficacy; cytotoxic lymphocytes; model ... See more keywords
NFATc1 controls the cytotoxicity of CD8+ T cells
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DOI: 10.1038/s41467-017-00612-6
Abstract: Cytotoxic T lymphocytes are effector CD8+ T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1−/− cytotoxic T… read more here.
Keywords: controls cytotoxicity; cd8 cells; cytotoxic lymphocytes; nfatc1 controls ... See more keywords
The metabolism of cells regulates their sensitivity to NK cells depending on p53 status
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DOI: 10.1038/s41598-022-07281-6
Abstract: Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism to adapt to their high growth. This change can stress cells and facilitate recognition by immune cells such as cytotoxic lymphocytes,… read more here.
Keywords: regulates sensitivity; metabolism cells; p53; cells regulates ... See more keywords
Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy
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DOI: 10.1080/2162402x.2016.1265721
Abstract: ABSTRACT The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally… read more here.
Keywords: lymphocytes improved; method cytokine; cytotoxic lymphocytes; improved method ... See more keywords
EBV‐specific cytotoxic T lymphocytes for refractory EBV‐associated post‐transplant lymphoproliferative disorder in solid organ transplant recipients: a systematic review
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DOI: 10.1111/tri.14107
Abstract: The use of Epstein–Barr virus‐specific cytotoxic T lymphocytes (EBV‐CTLs) in adoptive immunotherapy in hematopoietic stem cell transplantation (HSCT) patients with post‐transplantation lymphoproliferative disorder (PTLD) has demonstrated safety and effectiveness. EBV‐CTLs might also be the effective… read more here.
Keywords: ptld; ebv ctls; specific cytotoxic; lymphoproliferative disorder ... See more keywords
PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes
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DOI: 10.1126/sciadv.abc3243
Abstract: This research uncovered regulators of tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes. Major histocompatibility complex (MHC)–unrestricted cytotoxic lymphocytes (CLs) such as natural killer (NK) cells can detect and destroy tumor and virus-infected cells resistant to… read more here.
Keywords: tumor killing; unrestricted cytotoxic; cytotoxic lymphocytes; mhc unrestricted ... See more keywords
Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003549
Abstract: Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors owing to its robust desmoplasia, low immunogenicity, and recruitment of cancer-conditioned, immunoregulatory myeloid cells. These features strongly limit the success of immunotherapy as a… read more here.
Keywords: tumor; cancer; specific cytotoxic; myeloid cells ... See more keywords
CD161 Characterizes an Inflamed Subset of Cytotoxic T Lymphocytes Associated with Prolonged Survival in Human Papillomavirus–Driven Oropharyngeal Cancer
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DOI: 10.1158/2326-6066.cir-22-0454
Abstract: CD161 characterizes an inflamed subset of cytotoxic T lymphocytes that have high expression of immune checkpoints while retaining high cytotoxic capability. These cells can be reinvigorated by immune checkpoint blockade and are a biomarker for… read more here.
Keywords: cd161 characterizes; cytotoxic lymphocytes; cytotoxic; characterizes inflamed ... See more keywords
Characterization of the conserved regions of E1A protein from human adenovirus for reinforcement of cytotoxic T lymphocytes responses to the all genogroups causes ocular manifestation through an in silico approach
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Microbiology"
DOI: 10.18502/ijm.v14i5.10971
Abstract: Background and Objectives: Adenovirus species B, C, D, and E are the most common causes of ocular manifestations caused by adenoviruses. FDA-approved treatment agents for adenovirus infections are not available. Cell-mediated immunity is the major… read more here.
Keywords: causes ocular; e1a protein; cytotoxic lymphocytes; characterization conserved ... See more keywords
High-Throughput Microfluidic 3D Cytotoxicity Assay for Cancer Immunotherapy (CACI-IMPACT Platform)
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01133
Abstract: Adoptive cell transfer against solid tumors faces challenges to overcome tumor microenvironment (TME), which plays as a physical barrier and provides immuno-suppressive conditions. Classical cytotoxicity assays are widely used to measure killing ability of the… read more here.
Keywords: cytotoxicity assay; cytotoxic lymphocytes; cancer; cytotoxicity ... See more keywords