Hierarchical determinants in cytotoxic necrotizing factor (CNF) toxins driving Rho G-protein deamidation versus transglutamination
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DOI: 10.1128/mbio.01221-24
Abstract: ABSTRACT The cytotoxic necrotizing factor (CNF) family of AB-type bacterial protein toxins catalyze two types of modification on their Rho GTPase substrates: deamidation and transglutamination. It has been established that E. coli CNF1 and its… read more here.
Keywords: site; cnf toxins; cytotoxic necrotizing; transglutamination ... See more keywords
Bacterial Toxins and Targeted Brain Therapy: New Insights from Cytotoxic Necrotizing Factor 1 (CNF1)
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DOI: 10.3390/ijms19061632
Abstract: Pathogenic bacteria produce toxins to promote host invasion and, therefore, their survival. The extreme potency and specificity of these toxins confer to this category of proteins an exceptionally strong potential for therapeutic exploitation. In this… read more here.
Keywords: necrotizing factor; cytotoxic necrotizing; bacterial toxins; factor cnf1 ... See more keywords