Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum.
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DOI: 10.1021/acs.jnatprod.8b01034
Abstract: Six new macrolides named myrothecines D-G (1-4), 16-hydroxymytoxin B (5), and 14'-dehydrovertisporin (6), including four 10,13-cyclotrichothecane derivatives, in addition to 12 known compounds (7-18), were isolated from three endophytic Myrothecium roridum, IFB-E008, IFB-E009, and IFB-E012.… read more here.
Keywords: endophytic myrothecium; trichothecene macrolides; myrothecium roridum; cytotoxic trichothecene ... See more keywords
Cytotoxic trichothecene-type sesquiterpenes from the sponge-derived fungus Stachybotrys chartarum with tyrosine kinase inhibition
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DOI: 10.1039/c6ra26956g
Abstract: Bioassay-guided fractionation of the sponge (Niphates recondite)-associated fungus Stachybotrys chartarum revealed that the EtOAc fraction shows inhibitory effects against tumor cell lines. Chromatographic separation of the active fraction resulted in the isolation of 15 trichothecene-based… read more here.
Keywords: fungus stachybotrys; inhibition; cytotoxic trichothecene; stachybotrys chartarum ... See more keywords