Belinostat exerts antitumor cytotoxicity through the ubiquitin‐proteasome pathway in lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12064
Abstract: There have been advances in personalized therapy directed by molecular profiles in lung adenocarcinoma, but not in lung squamous cell carcinoma (SCC). The lack of actionable driver oncogenes in SCC has restricted the use of… read more here.
Keywords: cell carcinoma; squamous cell; belinostat; cytotoxicity ... See more keywords
Controlling C2C12 Cytotoxicity on Liquid Metal Embedded Elastomer (LMEE).
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202430
Abstract: Liquid metal embedded elastomers (LMEEs) are highly stretchable composites comprised of microscopic droplets of eutectic gallium-indium (EGaIn) liquid metal embedded in a soft rubber matrix. They have a unique combination of mechanical, electrical, and thermal… read more here.
Keywords: liquid metal; cytotoxicity; c2c12 cytotoxicity; metal embedded ... See more keywords
Antioxidant, DNA interaction, molecular docking and cytotoxicity studies of aminoethylpiperazine‐containing macrocyclic binuclear copper(II) complexes
Sign Up to like & getrecommendations! Published in 2017 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.3669
Abstract: A series of new macrocyclic binuclear copper(II) complexes of the type [Cu2L1–5(ClO4)](ClO4) (1–5) were synthesized by template condensation between precursor compounds 2,6-bis(4-aminoethylpiperazin-1-ylmethyl)-4-substituted phenols and 2,6-diformyl-4-substituted phenols. The synthesized precursors and complexes were characterized using regular… read more here.
Keywords: copper complexes; binuclear copper; macrocyclic binuclear; cytotoxicity ... See more keywords
Tandem synthesis, cytotoxicity, and in silico study of new 1,3,4‐oxadiazoles as potential thymidylate synthase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200170
Abstract: A new series of pyrrole‐linked mono‐ and bis(1,3,4‐oxadiazole) hybrids, attached to various arene units, was prepared using a two‐step tandem protocol. Therefore, a benzohydrazide derivative was condensed with the appropriate aldehydes in ethanol at 80°C… read more here.
Keywords: inhibition percentages; thymidylate synthase; tandem synthesis; cytotoxicity ... See more keywords
Structure–activity relationship study to improve cytotoxicity and selectivity of lonafarnib against breast cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200263
Abstract: Lonafarnib is designed as a farnesyltransferase (FTase) inhibitor and displays inhibitory activities against a wide range of tumor cells. However, a major disadvantage is its unselective activity and high cytotoxicity against nonmalignant cells. Therefore, we… read more here.
Keywords: cytotoxicity; cancer cells; breast cancer; activity ... See more keywords
Triazolo‐linked benzimidazoles as tubulin polymerization inhibitors and DNA intercalators: Design, synthesis, cytotoxicity, and docking studies
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200449
Abstract: A simple “click” protocol was employed in the quest of synthesizing 1,2,3‐triazole‐linked benzimidazoles as promising anticancer agents on various human cancer cell lines such as A549, HCT116, SK‐Mel‐28, HT‐29, and MCF‐7. Compound 12j demonstrated significant… read more here.
Keywords: dna; cytotoxicity; docking studies; tubulin polymerization ... See more keywords
2‐Phenylquinazolin‐4(3H)‐one scaffold as newly designed, synthesized VEGFR‐2 allosteric inhibitors with potent cytotoxicity through apoptosis
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200654
Abstract: New derivatives of 2‐phenylquinazolin‐4(3H)‐one were designed, synthesized, and biologically evaluated as potent allosteric kinase inhibitors with in situ cytotoxicity against MCF‐7 and HepG2 cells. Compounds 15 and 18 among the proposed compounds showed promising antiproliferative… read more here.
Keywords: vegfr; cytotoxicity; apoptosis; phenylquinazolin one ... See more keywords
Modulation of high mannose levels in N‐linked glycosylation through cell culture process conditions to increase antibody‐dependent cell‐mediated cytotoxicity activity for an antibody biosimilar
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Progress"
DOI: 10.1002/btpr.3176
Abstract: The regulatory approval of a biosimilar product is contingent on the favorable comparability of its safety and efficacy to that of the innovator product. As such, it is important to match the critical quality attributes… read more here.
Keywords: antibody; product; process; glycosylation ... See more keywords
Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201800769
Abstract: Malformin A1 (MA1) is a fungus‐produced cyclic pentapeptide. MA1 exhibits teratogenicity to plants, fibrinolysis‐enhancing activity, and cytotoxicity to mammalian cells. To clarify the cytotoxic mechanism of MA1, we screened for the genes involved in the cytotoxicity… read more here.
Keywords: crispr cas9; ma1; cytotoxicity; squalene epoxidase ... See more keywords
Cationic and Neutral N‐Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI‐60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen Species Formation
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800181
Abstract: A structurally diverse library of 14 gold(I) cationic bis(NHC) and neutral mono(NHC) complexes (NHC: N‐heterocyclic carbene) was synthesized and characterized in this work. Four of them were new cationic gold(I) complexes containing functionalized NHCs, and… read more here.
Keywords: thioredoxin reductase; gold; cytotoxicity; gold complexes ... See more keywords
Synthesis and Cytotoxicity of Octahydroepoxyisoindole‐7‐carboxylic Acids and Norcantharidin–Amide Hybrids as Norcantharidin Analogues
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900180
Abstract: Octahydroepoxyisoindole analogues of norcantharidin were accessed through a Diels–Alder reaction of an amine‐substituted furan with maleic anhydride and subsequent reduction of the bicyclo[2.2.1]heptene olefin. Despite retention of the carboxylate and the ether bridgehead known to… read more here.
Keywords: norcantharidin analogues; synthesis cytotoxicity; carboxylic acids; cytotoxicity octahydroepoxyisoindole ... See more keywords