Molecular Insights Into Di(2-Picolyl) Amine–Induced Cytotoxicity and Apoptosis in Human Kidney (HEK293) Cells
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DOI: 10.1177/1091581820921180
Abstract: Di(2-picolyl) amine (DPA) is a pyridine derivative known to chelate metal ions and thus has potential anticancer properties; however, its effect on normal cells remains unchartered necessitating further research. This study, therefore, investigated the mechanistic… read more here.
Keywords: cytotoxicity apoptosis; apoptosis; hek293 cells; picolyl amine ... See more keywords
A Novel Combination of Sotorasib and Metformin Enhances Cytotoxicity and Apoptosis in KRAS-Mutated Non-Small Cell Lung Cancer Cell Lines through MAPK and P70S6K Inhibition
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DOI: 10.3390/ijms24054331
Abstract: Novel inhibitors of KRAS with G12C mutation (sotorasib) have demonstrated short-lasting responses due to resistance mediated by the AKT-mTOR-P70S6K pathway. In this context, metformin is a promising candidate to break this resistance by inhibiting mTOR… read more here.
Keywords: metformin; cell; sotorasib; cytotoxicity apoptosis ... See more keywords