Synthesis and preliminary cytotoxicity evaluation of water soluble pentacyclic triterpenoid phosphonates
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-76816-w
Abstract: Synthesis, solubility and cytotoxicity evaluation of anionic phosphonates derived from betulin, betulinic acid, oleanolic acid and ursolic acid is reported. Phosphonate moieties were successfully installed at terpenoid C28 by carboxylic acid deprotonation/alkylation sequence using (dimethoxyphosphoryl)methyl… read more here.
Keywords: synthesis preliminary; cytotoxicity; water; triterpenoid phosphonates ... See more keywords
Cytotoxicity evaluation and metabolomic profiling of Spheciospongia vagabunda-associated fungi corroborated by in silico studies
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-04162-6
Abstract: Cancer incidence continues to increase every year. Scientists strive to search for new anticancer compounds to combat this disease. Appealingly, marine environmental niches are still an untapped scaffold for natural products with chemical and biomedical… read more here.
Keywords: cancer; spheciospongia; spheciospongia vagabunda; cytotoxicity evaluation ... See more keywords
Synthesis and cytotoxicity evaluation of olivacine-indole hybrids tethered by alkyl linkers.
Sign Up to like & getrecommendations! Published in 2021 at "Natural product research"
DOI: 10.1080/14786419.2021.1880401
Abstract: In this work, eleven new derivatives were prepared of the alkaloid olivacine (1), which was isolated from the bark of Aspidosperma australe. These compounds (7a-k) are hybrids of olivacine and indoles or carbazole, tethered by… read more here.
Keywords: olivacine; synthesis cytotoxicity; evaluation olivacine; cytotoxicity evaluation ... See more keywords
Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Research"
DOI: 10.1177/1747519820902674
Abstract: Acridine-based compounds possess anticancer activities by intercalating to DNA. Although they have chemotherapeutic potential, acridine-based compounds are not used to treat cancer. In this study, 2,N10-acridone derivatives are designed and synthesized based on acridone, a… read more here.
Keywords: synthesis cytotoxicity; molecular modeling; modeling studies; cytotoxicity evaluation ... See more keywords
Cytotoxicity Evaluation and Dereplication of Flavonoids-Guided by Antioxidant Activity and Total Phenolics Content from Ephedrantus amazonicus Leaves
Sign Up to like & getrecommendations! Published in 2024 at "Brazilian Archives of Biology and Technology"
DOI: 10.1590/1678-4324-2024231132
Abstract: : Plants synthesize secondary metabolites as a means of survival and competition. These metabolites are a potential source of natural antioxidants that may promote activity, favoring the control of cellular damage caused by oxidative stress.… read more here.
Keywords: evaluation dereplication; ephedrantus amazonicus; cytotoxicity evaluation; dereplication flavonoids ... See more keywords
Synthesis, Cytotoxicity Evaluation, and Molecular Dynamics of 4-Thiazolidinone Derivatives: A Potential Path to EGFR-Targeted Anticancer Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "Current medicinal chemistry"
DOI: 10.2174/0109298673400295250913044755
Abstract: INTRODUCTION Heterocyclic compounds remain cornerstones of contemporary drug discovery because their ring-embedded heteroatoms confer adaptable electronics, conformational flexibility, and a broad spectrum of biological activities. The skeleton structure of 4-thiazolidinone is present in many cytotoxically… read more here.
Keywords: egfr; evaluation molecular; cytotoxicity evaluation; dynamics thiazolidinone ... See more keywords
Synthesis, Cytotoxicity Evaluation and Molecular Docking Studyof N-Phenylpyrazoline Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Indonesian Journal of Chemistry"
DOI: 10.22146/ijc.45777
Abstract: The synthesis of N-phenylpyrazolines 1-5 was performed by the cyclocondensation of phenylhydrazine and appropriate chalcones that have been synthesized from our previous work. All of the compounds were elucidated for their structure using GC-MS, FTIR,… read more here.
Keywords: cell line; cytotoxicity evaluation; synthesis cytotoxicity; cell ... See more keywords
One-Pot Hydrothermal Preparation of Hydroxyapatite/Zinc Oxide Nanorod Nanocomposites and Their Cytotoxicity Evaluation against MG-63 Osteoblast-like Cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28010345
Abstract: In the present study, HAp-ZnO nanorod nanocomposites were successfully prepared using a customized hydrothermal reactor and studied for their compatibility against MG-63 osteoblast-like cells. The crystallinity, morphology, presence of chemical elements, and surface area properties… read more here.
Keywords: osteoblast like; microscopy; nanorod nanocomposites; cytotoxicity evaluation ... See more keywords
Formulation, Characterization, and Cytotoxicity Evaluation of Lactoferrin Functionalized Lipid Nanoparticles for Riluzole Delivery to the Brain
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14010185
Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the… read more here.
Keywords: brain; lactoferrin; cytotoxicity evaluation; formulation characterization ... See more keywords
Cytotoxicity Evaluation and Antioxidant Activity of a Novel Drink Based on Roasted Avocado Seed Powder
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11081083
Abstract: The avocado seed is an underused waste resulting from the processing of pulp. Polyphenols, fibers, and carotenoids are present in the seed, which also exhibits prophylactic, fungicidal, and larvicidal effects. Developing food products with avocado… read more here.
Keywords: avocado seed; novel drink; cytotoxicity evaluation; activity ... See more keywords
Cytotoxicity evaluation of a new ozonized olive oil
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Dentistry"
DOI: 10.4103/ejd.ejd_422_18
Abstract: Objective: The cytocompatibility of a new ozonized olive oil toward immortalized human gingival fibroblasts (HGFs) was evaluated and compared with two common antimicrobial agents based on chlorhexidine digluconate (CHX). Materials and Methods: The cytocompatibility of… read more here.
Keywords: cytotoxicity evaluation; evaluation new; new ozonized; ozonized olive ... See more keywords