Articles with "cza atm" as a keyword



Photo by eduschadesoares from unsplash

Evaluation of the in vitro activity of WCK 5222 (cefepime/zidebactam) and currently available combination therapies against single- and double-carbapenemase producing Enterobacteriaceae: Expanding the zone of hope.

Sign Up to like & get
recommendations!
Published in 2019 at "International journal of antimicrobial agents"

DOI: 10.1016/j.ijantimicag.2019.105863

Abstract: Cefepime/zidebactam (WCK 5222), a β-lactam/β-lactam enhancer antibiotic under development, was designed to retain in vitro activity against Enterobacteriaceae that simultaneously produce metallo-β-lactamase (MBL) and serine-β-lactamase (SBL). Currently, aztreonam (ATM) plus ceftazidime/avibactam (CZA) or meropenem/vaborbactam (M/V)… read more here.

Keywords: cefepime; vitro activity; cza atm; wck 5222 ... See more keywords

An NDM-Producing Escherichia coli Clinical Isolate Exhibiting Resistance to Cefiderocol and the Combination of Ceftazidime-Avibactam and Aztreonam: Another Step Towards Pan-β-Lactam Resistance

Sign Up to like & get
recommendations!
Published in 2023 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofad276

Abstract: Cefiderocol and ceftazidime-avibactam plus aztreonam (CZA-ATM) are preferred treatment regimens for NDM-producing infections. We report the case of a United States patient who traveled to India to receive a renal transplant. He subsequently experienced pyelonephritis… read more here.

Keywords: cza atm; cefiderocol; ceftazidime avibactam; ndm producing ... See more keywords
Photo by eduschadesoares from unsplash

Safety of Ceftazidime-Avibactam in Combination with Aztreonam (COMBINE) in a Phase I, Open-Label Study in Healthy Adult Volunteers

Sign Up to like & get
recommendations!
Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00935-22

Abstract: This phase I study evaluated the safety of the optimal ceftazidime-avibactam (CZA) with aztreonam (ATM) regimens identified in hollow fiber infection models of MBL-producing Enterobacterales. Eligible healthy subjects aged 18 to 45 years were assigned to… read more here.

Keywords: approved dose; cza atm; cza; atm every ... See more keywords
Photo by eduschadesoares from unsplash

Pharmacokinetics of Ceftazidime-Avibactam in Combination with Aztreonam (COMBINE) in a Phase 1, Open-Label Study of Healthy Adults

Sign Up to like & get
recommendations!
Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00936-22

Abstract: Scant pharmacokinetic (PK) data are available on ceftazidime-avibactam (CZA) and aztreonam (ATM) in combination, and it is unknown if CZA-ATM exacerbates alanine aminotransferase (ALT)/aspartate aminotransferase (AST) elevations relative to ATM alone. This phase 1 study… read more here.

Keywords: alt ast; cza atm; cza; ast elevations ... See more keywords