Evaluation of the in vitro activity of WCK 5222 (cefepime/zidebactam) and currently available combination therapies against single- and double-carbapenemase producing Enterobacteriaceae: Expanding the zone of hope.
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DOI: 10.1016/j.ijantimicag.2019.105863
Abstract: Cefepime/zidebactam (WCK 5222), a β-lactam/β-lactam enhancer antibiotic under development, was designed to retain in vitro activity against Enterobacteriaceae that simultaneously produce metallo-β-lactamase (MBL) and serine-β-lactamase (SBL). Currently, aztreonam (ATM) plus ceftazidime/avibactam (CZA) or meropenem/vaborbactam (M/V)… read more here.
Keywords: cefepime; vitro activity; cza atm; wck 5222 ... See more keywords
An NDM-Producing Escherichia coli Clinical Isolate Exhibiting Resistance to Cefiderocol and the Combination of Ceftazidime-Avibactam and Aztreonam: Another Step Towards Pan-β-Lactam Resistance
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DOI: 10.1093/ofid/ofad276
Abstract: Cefiderocol and ceftazidime-avibactam plus aztreonam (CZA-ATM) are preferred treatment regimens for NDM-producing infections. We report the case of a United States patient who traveled to India to receive a renal transplant. He subsequently experienced pyelonephritis… read more here.
Keywords: cza atm; cefiderocol; ceftazidime avibactam; ndm producing ... See more keywords
Safety of Ceftazidime-Avibactam in Combination with Aztreonam (COMBINE) in a Phase I, Open-Label Study in Healthy Adult Volunteers
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DOI: 10.1128/aac.00935-22
Abstract: This phase I study evaluated the safety of the optimal ceftazidime-avibactam (CZA) with aztreonam (ATM) regimens identified in hollow fiber infection models of MBL-producing Enterobacterales. Eligible healthy subjects aged 18 to 45 years were assigned to… read more here.
Keywords: approved dose; cza atm; cza; atm every ... See more keywords
Pharmacokinetics of Ceftazidime-Avibactam in Combination with Aztreonam (COMBINE) in a Phase 1, Open-Label Study of Healthy Adults
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00936-22
Abstract: Scant pharmacokinetic (PK) data are available on ceftazidime-avibactam (CZA) and aztreonam (ATM) in combination, and it is unknown if CZA-ATM exacerbates alanine aminotransferase (ALT)/aspartate aminotransferase (AST) elevations relative to ATM alone. This phase 1 study… read more here.
Keywords: alt ast; cza atm; cza; ast elevations ... See more keywords