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Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.105863
Abstract: Cefepime/zidebactam (WCK 5222), a β-lactam/β-lactam enhancer antibiotic under development, was designed to retain in vitro activity against Enterobacteriaceae that simultaneously produce metallo-β-lactamase (MBL) and serine-β-lactamase (SBL). Currently, aztreonam (ATM) plus ceftazidime/avibactam (CZA) or meropenem/vaborbactam (M/V)…
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Keywords:
cefepime;
vitro activity;
cza atm;
wck 5222 ... See more keywords
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Published in 2023 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofad276
Abstract: Cefiderocol and ceftazidime-avibactam plus aztreonam (CZA-ATM) are preferred treatment regimens for NDM-producing infections. We report the case of a United States patient who traveled to India to receive a renal transplant. He subsequently experienced pyelonephritis…
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Keywords:
cza atm;
cefiderocol;
ceftazidime avibactam;
ndm producing ... See more keywords
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Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00935-22
Abstract: This phase I study evaluated the safety of the optimal ceftazidime-avibactam (CZA) with aztreonam (ATM) regimens identified in hollow fiber infection models of MBL-producing Enterobacterales. Eligible healthy subjects aged 18 to 45 years were assigned to…
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Keywords:
approved dose;
cza atm;
cza;
atm every ... See more keywords
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Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00936-22
Abstract: Scant pharmacokinetic (PK) data are available on ceftazidime-avibactam (CZA) and aztreonam (ATM) in combination, and it is unknown if CZA-ATM exacerbates alanine aminotransferase (ALT)/aspartate aminotransferase (AST) elevations relative to ATM alone. This phase 1 study…
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Keywords:
alt ast;
cza atm;
cza;
ast elevations ... See more keywords