Evaluation of 6 monoclonal antibodies against Ser129-phosphorylated α-synuclein: Critical role of proteinase K antigen retrieval and superior sensitivity of the D1R1R clone in human skin biopsies.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaf036
Abstract: α-Synuclein is an essential component of synucleinopathies including Parkinson disease, dementia with Lewy bodies, and multiple system atrophy (MSA). Misfolded-α-synuclein inclusions that contain high levels of Serine-129 phosphorylated (pS129-α-syn) are key diagnostic markers. Skin biopsies… read more here.
Keywords: proteinase antigen; d1r1r; skin biopsies; antigen retrieval ... See more keywords