Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions
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DOI: 10.1038/npp.2017.254
Abstract: The dopamine D2 receptor (D2R), like many G-protein-coupled receptors, signals through G-protein- and β-arrestin-dependent pathways. Preferential activation of one of these pathways is termed functional selectivity or biased signaling and is a promising therapeutic strategy.… read more here.
Keywords: protein arrestin; d2r; d2r variants; d2r protein ... See more keywords