Absence of the KhpA and KhpB (JAG/EloR) RNA‐binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39
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DOI: 10.1111/mmi.13847
Abstract: Suppressor mutations were isolated that obviate the requirement for essential PBP2b in peripheral elongation of peptidoglycan from the midcells of dividing Streptococcus pneumoniae D39 background cells. One suppressor was in a gene encoding a single… read more here.
Keywords: overproduction; khpb; khpa; d39 ... See more keywords
StkP- and PhpP-Mediated Posttranslational Modifications Modulate the S. pneumoniae Metabolism, Polysaccharide Capsule, and Virulence
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DOI: 10.1128/iai.00296-22
Abstract: Pneumococcal Ser/Thr kinase (StkP) and its cognate phosphatase (PhpP) play a crucial role in bacterial cytokinesis. However, their individual and reciprocal metabolic and virulence regulation-related functions have yet to be adequately investigated in encapsulated pneumococci.… read more here.
Keywords: virulence; stkp; phpp; d39 ... See more keywords
Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39
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DOI: 10.3389/fmicb.2018.00321
Abstract: Pyrimidine nucleotides play an important role in the biosynthesis of activated nucleotide sugars (NDP-sugars). NDP-sugars are the precursors of structural polysaccharides in bacteria, including capsule, which is a major virulence factor of the human pathogen… read more here.
Keywords: d39; capsule; pneumoniae; mutant strain ... See more keywords