Potential of delphinidin-3-rutinoside extracted from Solanum melongena L. as promoter of osteoblastic MC3T3-E1 function and antagonist of oxidative damage
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DOI: 10.1007/s00394-018-1618-0
Abstract: PurposeIncreasing evidence suggests the potential use of natural antioxidant compounds in the prevention/treatment of osteoporosis. This study was undertaken to investigate the effects of purified delphinidin-3-rutinoside (D3R), isolated from Solanum melongena L., on osteoblast viability… read more here.
Keywords: solanum melongena; oxidative damage; d3r; mc3t3 ... See more keywords
The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists.
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DOI: 10.1021/acs.jmedchem.9b00702
Abstract: Because of the large degree of homology among dopamine D2-like receptors, discovering ligands capable of discriminating between the D2, D3, and D4 receptor subtypes remains a significant challenge. Previous work has exemplified the use of… read more here.
Keywords: chirality drug; significance chirality; d3r; bitopic ligands ... See more keywords
Dopamine D3 receptor ligands: a patent review (2014-2020).
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DOI: 10.1080/13543776.2022.2049240
Abstract: INTRODUCTION Compelling evidence identified D3 dopamine receptor (D3R) as a suitable target for therapeutic intervention on CNS-associated disorders, cancer and other conditions. Several efforts have been made toward developing potent and selective ligands for modulating… read more here.
Keywords: review; 2014 2020; dopamine receptor; receptor ... See more keywords
Pharmacological and Genetic Evidence of Dopamine Receptor 3-Mediated Vasoconstriction in Isolated Mouse Aorta
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DOI: 10.3390/biom11030418
Abstract: Dopamine receptors (DRs) are generally considered as mediators of vasomotor functions. However, when used in pharmacological studies, dopamine and/or DR agonists may not discriminate among different DR subtypes and may even stimulate alpha1 and beta-adrenoceptors.… read more here.
Keywords: mouse aorta; d3r; vasoconstriction isolated; vasoconstriction ... See more keywords
Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor
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DOI: 10.3390/biom11040570
Abstract: The dopamine D2/D3 receptor (D2R/D3R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D3R over D2R is attractive because of D3R’s restricted tissue distribution with potentially fewer… read more here.
Keywords: d2r; d3r; pharmacology; novel bitopic ... See more keywords
Unveiling the Differences in Signaling and Regulatory Mechanisms between Dopamine D2 and D3 Receptors and Their Impact on Behavioral Sensitization
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076742
Abstract: Dopamine receptors are classified into five subtypes, with D2R and D3R playing a crucial role in regulating mood, motivation, reward, and movement. Whereas D2R are distributed widely across the brain, including regions responsible for motor… read more here.
Keywords: unveiling differences; d3r; dopamine receptors; sensitization ... See more keywords
Identifying Dopamine D3 Receptor Ligands through Virtual Screening and Exploring the Binding Modes of Hit Compounds
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DOI: 10.3390/molecules28020527
Abstract: The dopamine D3 receptor (D3R) is an important central nervous system target for treating various neurological diseases. D3R antagonists modulate the improvement of psychostimulant addiction and relapse, while D3R agonists can enhance the response to… read more here.
Keywords: d3r; dopamine receptor; virtual screening; hit compounds ... See more keywords