Highly Potent and Selective Dopamine D4 Receptor Antagonists Potentially Useful for the Treatment of Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00840
Abstract: To better understand the role of dopamine D4 receptor (D4R) in glioblastoma (GBM), in the present paper, new ligands endowed with high affinity and selectivity for D4R were discovered starting from the brain penetrant and… read more here.
Keywords: glioblastoma; dopamine receptor; dopamine; d4r ... See more keywords
Methylation-related metabolic effects of D4 dopamine receptor expression and activation
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DOI: 10.1038/s41398-019-0630-3
Abstract: D4 dopamine receptor (D4R) activation uniquely promotes methylation of plasma membrane phospholipids, utilizing folate-derived methyl groups provided by methionine synthase (MS). We evaluated the impact of D4R expression on folate-dependent phospholipid methylation (PLM) and MS… read more here.
Keywords: methylation; expression; activation; receptor ... See more keywords
Functional and pharmacological role of the dopamine D4 receptor and its polymorphic variants
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DOI: 10.3389/fendo.2022.1014678
Abstract: The functional and pharmacological significance of the dopamine D4 receptor (D4R) has remained the least well understood of all the dopamine receptor subtypes. Even more enigmatic has been the role of the very prevalent human… read more here.
Keywords: dopamine receptor; role; functional pharmacological; d4r ... See more keywords
Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1087171
Abstract: The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction. D4R has also… read more here.
Keywords: desensitization; dopamine receptor; dopamine; d4r ... See more keywords