Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low- to middle-income countries
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DOI: 10.1186/s40249-017-0377-0
Abstract: BackgroundThymidine analogs, namely AZT (Zidovudine or Retrovir™) and d4T (Stavudine or Zerit™) are antiretroviral drugs still employed in over 75% of first line combination antiretroviral therapy (cART) in Kampala, Uganda despite aversion to prescribing these… read more here.
Keywords: first line; d4t; treatment; resistance ... See more keywords
Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy
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DOI: 10.1371/journal.pone.0204111
Abstract: Background The use of the HIV antiretroviral drug stavudine (d4T), a thymidine analogue, is associated with the development of mitochondrial toxicities such as sensory neuropathy (SN). Genetic variation in genes relating to d4T transport and… read more here.
Keywords: variation; d4t; sensory neuropathy; occurrence ... See more keywords