Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06035
Abstract: Background Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike (S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study… read more here.
Keywords: d614g mutation; analysis; middle east; sars cov ... See more keywords
dsmCRISPR: Dual synthetic mismatches CRISPR/Cas12a-based detection of SARS-CoV-2 D614G mutation
Sign Up to like & getrecommendations! Published in 2021 at "Virus Research"
DOI: 10.1016/j.virusres.2021.198530
Abstract: Fast evolving of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has caused the spreading of COVID-19 disease rapidly around the globe. The mutation, especially in the gene encoding spike protein has helped the virus… read more here.
Keywords: detection sars; d614g mutation; cov d614g; sars cov ... See more keywords
The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.ade5085
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) egress occurs by lysosomal exocytosis. We show that the Spike D614G mutation enhances Spike trafficking to lysosomes, drives Spike-mediated reprogramming of lysosomes, and reduces cell surface Spike expression… read more here.
Keywords: d614g mutation; furin cleavage; trafficking lysosomes; mutation ... See more keywords
The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01301-22
Abstract: The first SARS-CoV-2 variant that spread worldwide in early 2020 carried a D614G mutation in the viral spike, making this protein more stable in its cleaved form at the surface of virions. The Alpha and… read more here.
Keywords: d614g mutation; cleavage site; spike; mutation ... See more keywords
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types
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DOI: 10.7554/elife.65365
Abstract: A novel variant of the SARS-CoV-2 virus carrying a point mutation in the Spike protein (D614G) has recently emerged and rapidly surpassed others in prevalence. This mutation is in linkage disequilibrium with an ORF1b protein… read more here.
Keywords: d614g; d614g mutation; spike d614g; sars cov ... See more keywords