Proper E‐cadherin membrane location in colon requires Dab2 and it modifies by inflammation and cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29917
Abstract: We reported that Disabled‐2 (Dab2) is located at the apical membrane in suckling rat intestine. Here, we discovered that, in colon of suckling and adult mouse and of adult human, Dab2 is only at lateral… read more here.
Keywords: dab2; requires dab2; inflammation cancer; colon ... See more keywords
Loss of Disabled-2 Expression in Pancreatic Cancer Progression
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43992-z
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by rapid metastasis and resistance to chemotherapy, properties that are shared by cancer stem cells (CSCs). In pancreatic cancer, tumor cells which possess the… read more here.
Keywords: dab2; pancreatic cancer; expression pancreatic; cancer ... See more keywords
Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-11-0510
Abstract: The kidney proximal tubule (PT) elaborates a uniquely high capacity apical endocytic pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier. Megalin and cubilin/amnionless (CUBAM) receptors engage Dab2 in these cells… read more here.
Keywords: megalin; megalin cubilin; endocytic pathway; dab2 ... See more keywords
Sporothrix schenckii regulates macrophage inflammatory responses via the c-JUN-induced Dab2 transcription.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental dermatology"
DOI: 10.1111/exd.14580
Abstract: Macrophages, which serve as a bridge between innate and adaptive immunity, play an important role in sporotrichosis. Sporothrix schenckii infections can produce immune responses such as macrophage polarization and inflammatory factor secretion. In the early… read more here.
Keywords: expression; sporothrix schenckii; jun; dab2 ... See more keywords
Functional links between Disabled‐2 Ser723 phosphorylation and thrombin signaling in human platelets
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13785
Abstract: Essentials Disabled‐2 (Dab2) phosphorylation status in thrombin signaling of human platelet was investigated. Ser723 was the major Dab2 phosphorylation site in human platelets stimulated by thrombin. Dab2 S723 phosphorylation (pS723) caused the dissociation of Dab2‐CIN85… read more here.
Keywords: human platelets; phosphorylation; dab2; signaling human ... See more keywords
Disabled-2 (DAB2): A Key Regulator of Anti- and Pro-Tumorigenic Pathways
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010696
Abstract: Disabled-2 (DAB2), a key adaptor protein in clathrin mediated endocytosis, is implicated in the regulation of key signalling pathways involved in homeostasis, cell positioning and epithelial to mesenchymal transition (EMT). It was initially identified as… read more here.
Keywords: pro tumorigenic; disabled dab2; key regulator; dab2 key ... See more keywords
miR‑149 promotes the myocardial differentiation of mouse bone marrow stem cells by targeting Dab2.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2018.8903
Abstract: To investigate the role of microRNA (miR)‑149 in the cardiac differentiation of mouse bone marrow mesenchymal stem cells (MSCs) in vitro, MSCs were infected with a lentivirus overexpressing miR‑149 and the effect on cardiac differentiation was… read more here.
Keywords: dab2; mir 149; mouse bone; differentiation ... See more keywords