Proper E‐cadherin membrane location in colon requires Dab2 and it modifies by inflammation and cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29917
Abstract: We reported that Disabled‐2 (Dab2) is located at the apical membrane in suckling rat intestine. Here, we discovered that, in colon of suckling and adult mouse and of adult human, Dab2 is only at lateral… read more here.
Keywords: dab2; requires dab2; inflammation cancer; colon ... See more keywords
Loss of Disabled-2 Expression in Pancreatic Cancer Progression
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43992-z
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by rapid metastasis and resistance to chemotherapy, properties that are shared by cancer stem cells (CSCs). In pancreatic cancer, tumor cells which possess the… read more here.
Keywords: dab2; pancreatic cancer; expression pancreatic; cancer ... See more keywords
Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-06047-2
Abstract: Disabled 2 (Dab2), an adaptor protein, is up regulated in the hair follicle stem cells (HFSCs); however, its role in any tissue stem cells has not been studied. In the present study, we have reported… read more here.
Keywords: adaptor protein; hair follicle; stem cells; dab2 ... See more keywords
Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-11-0510
Abstract: The kidney proximal tubule (PT) elaborates a uniquely high capacity apical endocytic pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier. Megalin and cubilin/amnionless (CUBAM) receptors engage Dab2 in these cells… read more here.
Keywords: megalin; megalin cubilin; endocytic pathway; dab2 ... See more keywords
Sporothrix schenckii regulates macrophage inflammatory responses via the c-JUN-induced Dab2 transcription.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental dermatology"
DOI: 10.1111/exd.14580
Abstract: Macrophages, which serve as a bridge between innate and adaptive immunity, play an important role in sporotrichosis. Sporothrix schenckii infections can produce immune responses such as macrophage polarization and inflammatory factor secretion. In the early… read more here.
Keywords: expression; sporothrix schenckii; jun; dab2 ... See more keywords
Disabled 2 (Dab2) Regulates Tumour Progression in Skin Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Experimental Dermatology"
DOI: 10.1111/exd.70009
Abstract: Dab2 is an endocytic adaptor protein involved in various physiological processes and signaling pathways. Dab2 is deregulated in various cancers; however, its role in skin squamous cell carcinoma ( SCC) has not been elucidated yet.… read more here.
Keywords: tumour progression; dab2; cell; squamous cell ... See more keywords
Functional links between Disabled‐2 Ser723 phosphorylation and thrombin signaling in human platelets
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13785
Abstract: Essentials Disabled‐2 (Dab2) phosphorylation status in thrombin signaling of human platelet was investigated. Ser723 was the major Dab2 phosphorylation site in human platelets stimulated by thrombin. Dab2 S723 phosphorylation (pS723) caused the dissociation of Dab2‐CIN85… read more here.
Keywords: human platelets; phosphorylation; dab2; signaling human ... See more keywords
The role of Dab2 in regulating angiogenesis in diabetes
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.0856
Abstract: Background: Diabetes-related vascular complications underlie a number of life-threatening conditions including cardiovascular disease, stroke, and peripheral limb ulcerations, the latter of which can lead to severe infections and a multitude of serious medical issues. Vascular… read more here.
Keywords: angiogenesis diabetes; physiology; angiogenesis; wound healing ... See more keywords
Abstract 4358978: Dab2 Protects Endothelial Function and Promotes Atheroma Regression
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4358978
Abstract: Introduction: Endothelial cell dysfunction causes recruitment of inflammatory cells to the intima, initiating atheromatous plaque build-up. Atherosclerosis underlies myocardial infarction and stroke which remain leading causes of death in the US. Identifying key regulators that… read more here.
Keywords: protects endothelial; function; endothelial dab2; dab2 ... See more keywords
E3 Ubiquitin Ligase TRIM16-Mediated K63-linked Ubiquitination of DAB2 Enhances Integrin β1 Endocytosis to Facilitate Vascular Calcification.
Sign Up to like & getrecommendations! Published in 2025 at "Circulation research"
DOI: 10.1161/circresaha.125.326520
Abstract: BACKGROUND Vascular calcification is highly prevalent in patients with chronic kidney disease (CKD), and the underlying mechanisms remain elusive. Several studies have indicated an important role of protein ubiquitination in vascular calcification. However, the role… read more here.
Keywords: ckd; trim16; endocytosis; vascular calcification ... See more keywords
STAT3–mediated up-regulation of DAB2 via SRC-YAP1 signaling axis promotes Helicobacter pylori-driven gastric tumorigenesis
Sign Up to like & getrecommendations! Published in 2024 at "Biomarker Research"
DOI: 10.1186/s40364-024-00577-x
Abstract: Background Helicobacter pylori ( H pylori ) infection is the primary cause of gastric cancer (GC). The role of Disabled-2 (DAB2) in GC remains largely unclear. This study aimed to investigate the role of DAB2… read more here.
Keywords: yap1; tumorigenesis; dab2; helicobacter pylori ... See more keywords