DACH1 suppresses epithelial to mesenchymal transition (EMT) through Notch1 pathway and reverses progestin resistance in endometrial carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2317
Abstract: Progestin resistance limits the effectiveness of progestin therapy in endometrial carcinoma for patients who desire to preserve fertility. To investigate the molecular mechanism of progestin resistance in endometrial carcinoma, we performed microarray analysis among Ishikawa… read more here.
Keywords: dach1; progestin resistance; endometrial carcinoma; resistance ... See more keywords
DACH1 DOWNREGULATION DELINEATE A LYMPHOID PRIMED PROGENITOR (LPP) POPULATION WITHIN THE MPP4 CLUSTER
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.448
Abstract: Classical models of haematopoiesis dictate that a single hematopoietic stem cell (HSC) with self-renewal capacity can give rise to all the hematopoietic lineage through subsequent division and loss of potential. This loss of potential is… read more here.
Keywords: primed progenitor; progenitor; dach1; mpp4 cluster ... See more keywords
DACH1, a novel target of miR-218, participates in the regulation of cell viability, apoptosis, inflammatory response, and epithelial-mesenchymal transition process in renal tubule cells treated by high-glucose
Sign Up to like & getrecommendations! Published in 2020 at "Renal Failure"
DOI: 10.1080/0886022x.2020.1762647
Abstract: Abstract Objective This report was designed to assess the functional role of miR-218/dachshund family transcription factor 1 (DACH1) in diabetic kidney disease (DKD) and investigate its possible molecular mechanism. Materials and Methods From the GEO… read more here.
Keywords: cell viability; mir 218; apoptosis; dach1 ... See more keywords
DACH1 induced stemness of intestinal organoids by directly suppressing bone morphogenetic proteins (BMP) signaling and contributes to intestinal tumorigenesis
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DOI: 10.1093/annonc/mdz246.110
Abstract: Abstract Background Crypt base cells are candidates for intestinal epithelial stem cells (ISC). But limited progress has been made concerning the modulation of stem cells. DACH1 is upregulated in LGR5+ ISC cells with stemness maintenance.… read more here.
Keywords: dach1 induced; bmp signaling; dach1; stem cell ... See more keywords
Dach1 is essential for maintaining normal mature podocytes
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0303910
Abstract: Dach1 is highly expressed in normal podocytes, but this expression rapidly disappears after podocyte injury. To investigate the role of Dach1 in podocytes in vivo, we analyzed global, podocyte-specific, and inducible Dach1 knockout mice. Global… read more here.
Keywords: mice; dach1; dach1 knockout; mature podocytes ... See more keywords
Identification and verification of the temozolomide resistance feature gene DACH1 in gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1120103
Abstract: Introduction The most important chemotherapy treatment for glioma patients is temozolomide. However, the development of drug resistance severely restricts the use of temozolomide. Therefore, elucidating the mechanism of temozolomide resistance, enhancing temozolomide sensitivity, and extending… read more here.
Keywords: temozolomide resistance; resistance; dach1; gene dach1 ... See more keywords