DACH1 induced stemness of intestinal organoids by directly suppressing bone morphogenetic proteins (BMP) signaling and contributes to intestinal tumorigenesis
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DOI: 10.1093/annonc/mdz246.110
Abstract: Abstract Background Crypt base cells are candidates for intestinal epithelial stem cells (ISC). But limited progress has been made concerning the modulation of stem cells. DACH1 is upregulated in LGR5+ ISC cells with stemness maintenance.… read more here.
Keywords: dach1 induced; bmp signaling; dach1; stem cell ... See more keywords