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   Articles with "dact1" as a keyword



Dact1, a Wnt‐Pathway Inhibitor, Mediates Human Mesangial Cell TGF‐β1‐Induced Apoptosis

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recommendations! Published in 2017 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.25636

Abstract: Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of men and women of all ages and racial groups. Loss of mesangial cells (MC) represents an early common feature in the… read more here.

Keywords: apoptosis; dact1; tgf; cell ... See more keywords

Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-57658-0

Abstract: Convergent extension (CE) is a universal morphogenetic engine that promotes polarized tissue extension. In vertebrates, CE is regulated by non-canonical Wnt ligands signaling through “core” proteins of the planar cell polarity (PCP) pathway, including the… read more here.

Keywords: signalosome; oligomerization; extension; dact1 ... See more keywords

Disheveled binding antagonist of β-catenin 1 interacted with β-catenin and connexin 43 in human-induced pluripotent stem cells-derived cardiomyocytes

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2070448

Abstract: ABSTRACT Previously, we demonstrated that the disheveled binding antagonist of β-catenin 1 (DACT1) was involved in atrial fibrillation by regulating the reorganization of connexin 43 and β-catenin in cardiomyocytes. Little is known, however, about DACT1… read more here.

Keywords: catenin connexin; dact1; catenin; stem cells ... See more keywords

FTO alleviated the diabetic nephropathy progression by regulating the N6-methyladenosine levels of DACT1

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recommendations! Published in 2025 at "Open Life Sciences"

DOI: 10.1515/biol-2022-1049

Abstract: Abstract Diabetic nephropathy (DN) is one of the most important microvascular complications of diabetes. The role of epigenetic regulation in DN has attracted much attention recently. This research was performed to explore the role of… read more here.

Keywords: alleviated diabetic; fto alleviated; progression; dact1 ... See more keywords