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Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00657
Abstract: Diacylglycerol lipase-beta (DAGLβ) hydrolyzes arachidonic acid (AA)-containing diacylglycerols to produce bioactive lipids including endocannabinoids and AA-derived eicosanoids involved in regulation of inflammatory signaling. Previously, we demonstrated that DAGLβ inactivation using the triazole urea inhibitor KT109…
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Keywords:
diacylglycerol lipase;
inhibitors macrophages;
delivery;
lipase beta ... See more keywords
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Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1092024
Abstract: Introduction Lipids and fatty acids are key components in metabolic processes of the human placenta, thereby contributing to the development of the fetus. Placental dyslipidemia and aberrant activity of lipases have been linked to diverse…
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Keywords:
human placenta;
inhibition;
activity;
dagl ... See more keywords