Deletion of PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1) worsens salt sensitive hypertension and kidney damage in Dahl S rats
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DOI: 10.1152/physiol.2023.38.s1.5731416
Abstract: Prex1 (Phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1) is a Rac-specific guanine nucleotide exchanging factor and an integrator of signaling between Rac1 and protein kinase A (PKA). Both Rac1 and PKA are involved in pathways associated with… read more here.
Keywords: hypertension; prex1; physiology; salt sensitive ... See more keywords
Divergent Sex-Specific Effects of Toll-like Receptor 4 and Cluster of Differentiation 14 in Dahl Salt-Sensitive Hypertension
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DOI: 10.1152/physiol.2023.38.s1.5734225
Abstract: Renal inflammation accompanies hypertension and renal damage in Dahl Salt-Sensitive rats fed a high salt diet (HS, 4.0% NaCl). Via a transcriptomics approach, we previously found cluster of differentiation 14 (CD14) and toll-like receptor 4… read more here.
Keywords: physiology; sensitive hypertension; salt sensitive; dahl ... See more keywords
Abstract 152: Downregulation of Placental Genes are Associated With the Development of Maternal Syndrome in Dahl Salt-Sensitive Rats
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DOI: 10.1161/hyp.74.suppl_1.152
Abstract: The Dahl Salt-Sensitive rat maintained on a low salt, casein-based diet (SSC) develops maternal syndrome (hypertension and proteinuria) compared to virgin controls. Our group has previously demonstrated that a substitution of the casein protein for… read more here.
Keywords: salt; development maternal; dahl; maternal syndrome ... See more keywords
Abstract P3035: Role of T Cells in Sex Differences in Blood Pressure Elevation and Adipose Tissue Expansion Following Chronic High Fat Diet Feeding in Dahl Rats
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DOI: 10.1161/hyp.74.suppl_1.p3035
Abstract: Diets high in saturated fats are increasingly linked to the development of hypertension, yet the mechanisms by which high saturated fat diet (HFD) increases blood pressure remain unclear. Although young women are typically protected from… read more here.
Keywords: hfd; expansion; blood pressure; dahl ... See more keywords