Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.01.036
Abstract: &NA; The role of 2,4‐diamino‐6‐hydroxypyrimidine (DAHP), on cellular‐senescence remains unclear as differential effects of DAHP have been reported in cardiovascular and cerebrovascular systems. We investigated the effect of pharmacologically‐induced guanosine‐triphosphate‐cyclohydrolase1 (GTPCH1)‐inhibition, through DAHP, on cellular‐senescence… read more here.
Keywords: guanosine triphosphate; triphosphate cyclohydrolase1; phosphorylation caveolin1; senescence ... See more keywords
Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b01211
Abstract: 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthase catalyzes an aldol-like reaction of phosphoenolpyruvate (PEP) with erythrose 4-phosphate (E4P) to form DAHP in the first step of the shikimate biosynthetic pathway. DAHP oxime, in which an oxime replaces the ketone,… read more here.
Keywords: inhibitor; dahp oxime; dahp synthase; dahp ... See more keywords