Protective effect of daidzein against streptozotocin‐induced Alzheimer's disease via improving cognitive dysfunction and oxidative stress in rat model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22319
Abstract: Oxidative stress is performing an essential role in developing Alzheimer's disease (AD), and age‐related disorder and other neurodegenerative diseases. In existing research, we have aimed at investigating the daidzein (4′,7‐dihydroxyisoflavone) effect (10 and 20 mg/kg of… read more here.
Keywords: daidzein; effect; streptozotocin; effect daidzein ... See more keywords
Daidzein cocrystals: An opportunity to improve its biopharmaceutical parameters
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e02669
Abstract: The present study involves the contribution of cocrystallization towards the modification of the biopharmaceutical parameters of poorly watersoluble plant-originated isoflavone, daidzein (DAID). The cocrystals were prepared with GRAS status coformers i.e., isonicotinamide, theobromine and cytosine… read more here.
Keywords: cocrystals opportunity; daidzein cocrystals; opportunity improve; daidzein ... See more keywords
High Titer of (S)-Equol Synthesis from Daidzein in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00378
Abstract: (S)-Equol is the terminal metabolite of daidzein and plays important roles in human health. However, due to anaerobic inefficiency, limited productivity in (S)-equol-producing strains often hinders (S)-equol mass production. Here, a multi-enzyme cascade system was… read more here.
Keywords: daidzein; synthesis; titer; synthesis pathway ... See more keywords
Biotransformation of Daidzein to Diadzein-7-Glucoside and Its Anti-allergic Activity
Sign Up to like & getrecommendations! Published in 2017 at "Natural Product Communications"
DOI: 10.1177/1934578x1701201121
Abstract: The biotransformation of daidzein and its diacetate was investigated using cultured plant cells of Phytolacca americana as biocatalysts. Daidzein was glucosylated to the corresponding 7-O-β-D-glucoside. On the other hand, daidzein diacetate was hydrolyzed to daidzein,… read more here.
Keywords: diadzein glucoside; daidzein diadzein; biotransformation daidzein; daidzein ... See more keywords
Isolation and identification of an isoflavone reducing bacterium from feces from a pregnant horse
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223503
Abstract: The aim of this research was to isolate bacteria capable of biotransforming daidzein from fresh feces from pregnant horses. A Hungate anaerobic roller tube was used for anaerobic culture. Single colonies were picked at random… read more here.
Keywords: bacterium; identification isoflavone; daidzein; feces pregnant ... See more keywords
Daidzein and its Effects on Brain.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867323666161101140214
Abstract: Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an… read more here.
Keywords: daidzein effects; chemistry; daidzein; effects brain ... See more keywords
Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT1 and Mas receptors and microRNAs 33a and 27a
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.66572.14609
Abstract: Objective(s): Chronic kidney disease (CKD), accompanied by renal dysfunction, fibrosis, and apoptosis, is highly prevalent in postmenopausal women. We tested the hypothesis that isoflavone daidzein may ameliorate renal dysfunction and fibrosis through angiotensin II type… read more here.
Keywords: postmenopausal; daidzein; dysfunction fibrosis; fibrosis ... See more keywords
Daidzein alleviated the pathologies in intestinal tissue against ischemia-reperfusion.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202302_31389
Abstract: OBJECTIVE The aim of this study was to investigate the effect of daidzein against intestinal ischemia-reperfusion injury in rats. MATERIALS AND METHODS Thirty male Wistar albino rats with a mean weight of 200-250 gr were… read more here.
Keywords: group; ischemia reperfusion; daidzein; daidzein group ... See more keywords
7,3′,4′-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses α-Melanocyte-Stimulating Hormone-Induced Melanogenesis by Targeting Melanocortin 1 Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.577284
Abstract: 7,3′,4′-Trihydroxyisoflavone (7,3′,4′-THIF) is a metabolite of daidzein which is a representative isoflavone found in soybean. Recent studies suggested that 7,3′,4′-THIF exerts a hypopigmentary effect in B16F10 cells, however, its underlying molecular mechanisms and specific target… read more here.
Keywords: msh induced; daidzein; melanocortin receptor; targeting melanocortin ... See more keywords
Neuroprotective Effect of Daidzein Extracted From Pueraria lobate Radix in a Stroke Model Via the Akt/mTOR/BDNF Channel
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.772485
Abstract: Daidzein is a plant isoflavonoid primarily isolated from Pueraria lobate Radix as the dry root of P. lobata (Wild.) Ohwi, have long been used as nutraceutical and medicinal herb in China. Despite the report that… read more here.
Keywords: daidzein; akt mtor; pueraria lobate; mtor bdnf ... See more keywords
An Efficient UPLC-MS/MS Method Established to Detect Relugolix Concentration in Rat Plasma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.874973
Abstract: Relugolix, a gonadotropin-releasing hormone (GnRH) receptor antagonist, has been well studied in the treatment of endometriosis symptomatic. It is mainly metabolized by the CYP3A subfamily of P450 enzymes, while minorly metabolized by CYP2C8. Daidzein in… read more here.
Keywords: efficient uplc; day; daidzein; relugolix ... See more keywords