High-salt intake accelerates functional and histological renal damage associated with renal tissue overexpression of (pro)renin receptors and AT1 receptors in spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-020-01888-7
Abstract: Objective This study aimed to investigate the effect of combination of high-salt intake and hypertension on renal functional and histological damage, associated with renal (pro)renin receptor [(P)RR] and AT1 receptor in rats. Methods Wistar Kyoto… read more here.
Keywords: associated renal; functional histological; salt intake; damage associated ... See more keywords
Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.08.018
Abstract: We have recently reported that a short course of morphine, starting 10days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization… read more here.
Keywords: associated molecular; morphine; nlrp3 inflammasomes; molecular patterns ... See more keywords
DANGER SIGNALS IN LIVER INJURY AND RESTORATION OF HOMEOSTASIS.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2020.04.033
Abstract: Damage-associated molecular patterns are signaling molecules involved in inflammatory responses and restoration of homeostasis. Chronic release of these molecules can also promote inflammation, including in the context of liver disease. This comprehensive summary describes the… read more here.
Keywords: associated molecular; liver; molecular patterns; damage associated ... See more keywords
Plasma-synthesized mussel-inspired gold nanoparticles promote autophagy-dependent damage-associated molecular pattern release to potentiate immunogenic cancer cell death
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2021.05.035
Abstract: Abstract The development of an efficient tumor-specific therapeutic approach, which functions against the primary tumor and also repairs the host immune system to eradicate distant tumors, remains a clinical issue. Herein, this study focuses on… read more here.
Keywords: cell death; pda nps; associated molecular; damage associated ... See more keywords
Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2016.08.012
Abstract: OBJECTIVE To evaluate the anti-inflammatory mechanism of action of Chondroitin Sulphate (CS). DESIGN THP-1 macrophages were cultured with a range of sizes and concentrations of HA fragments with TLR4 (LPS in a physiologically relevant concentration… read more here.
Keywords: chondroitin sulphate; associated molecules; activity induced; damage associated ... See more keywords
Damage-associated molecular patterns and their role as initiators of inflammatory and auto-immune signals in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "International Reviews of Immunology"
DOI: 10.1080/08830185.2017.1365146
Abstract: ABSTRACT Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released into the extracellular space under conditions of activation, cellular stress, or tissue damage. These molecules are recognized by pattern-recognition receptors (PRRs) and can induce… read more here.
Keywords: auto; associated molecular; molecular patterns; auto immune ... See more keywords
Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
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DOI: 10.1093/brain/awaa246
Abstract: Parkin/PINK1 deficiency impairs mitophagy in mice, leading to the release of mitochondrial DNA (mtDNA) and triggering inflammation. Borsche et al. now demonstrate elevated serum Interleukin 6 and circulating cell-free mtDNA also in patients with Parkin/PINK1… read more here.
Keywords: mitochondrial damage; inflammation highlights; highlights biomarkers; inflammation ... See more keywords
Danger Signals in the ICU
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003007
Abstract: Objectives: Sterile and infectious critical illnesses often result in vasoplegic shock and a robust systemic inflammatory response that are similar in presentation. The innate immune system is at the center of the response to both… read more here.
Keywords: associated molecular; response; molecular patterns; damage associated ... See more keywords
Regulatory T cells, damage-associated molecular patterns, and myeloid-derived suppressor cells in bronchoalveolar lavage fluid interlinked with chronic obstructive pulmonary disease severity
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029208
Abstract: Abstract The role of regulatory T cells (Tregs), damage-associated molecular patterns (DAMPs), and myeloid-derived suppressor cells (MDSCs) in the mechanism of innate and adaptive immune responses in chronic obstructive pulmonary disease (COPD) is not well… read more here.
Keywords: regulatory cells; damage associated; myeloid derived; disease ... See more keywords
Kidney damage associated with vesico ureteric reflux.
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DOI: 10.1097/mop.0000000000000996
Abstract: PURPOSE OF REVIEW The aim of this review is to highlight the most recent developments in the understanding of kidney damage associated with vesico ureteral reflux. The severe damage, with major adverse long-term sequelae, was… read more here.
Keywords: kidney damage; damage; damage associated; reflux ... See more keywords
NEUTROPHIL HETEROGENEITY IN SEPSIS: THE ROLE OF DAMAGE-ASSOCIATED MOLECULAR PATTERNS
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002019
Abstract: ABSTRACT Sepsis is a severe inflammatory disease syndrome caused by the dysregulated host response to infection. Neutrophils act as the first line of defense against pathogens by releasing effector molecules such as reactive oxygen species,… read more here.
Keywords: sepsis; heterogeneity; damage associated; damage ... See more keywords