Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Microbiology"
DOI: 10.1007/s12275-020-9520-x
Abstract: The DNA damage checkpoint signaling pathway is a highly conserved surveillance mechanism that ensures genome integrity by sequential activation of protein kinase cascades. In mammals, the main pathway is orchestrated by two central sensor kinases,… read more here.
Keywords: dna damage; checkpoint signaling; damage checkpoint; dna ... See more keywords
Phosphatase-dependent fluctuations in DNA-damage checkpoint activation at partially defective telomeres.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.030
Abstract: Telomeres protect the ends of eukaryotic chromosomes, and telomere shortening causes irreversible cell-cycle arrest through activation of the DNA-damage checkpoint. In this study, we found that deletion of PPH3, encoding a 2A-like protein phosphatase, accelerated… read more here.
Keywords: dna damage; damage checkpoint; phosphatase dependent; activation ... See more keywords
Mck1 kinase is a new player in the DNA damage checkpoint pathway
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008372
Abstract: The DNA damage checkpoint is a signal transduction cascade with three layers of kinases. Checkpoint kinases are conventionally defined as kinases that are activated by DNA damage— either directly or by upstream kinases—and phosphorylate targets… read more here.
Keywords: dna damage; damage checkpoint; dun1; dna ... See more keywords
The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress
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DOI: 10.7554/elife.29953
Abstract: Genotoxic stress causes proliferating cells to activate the DNA damage checkpoint, to assist DNA damage recovery by slowing cell cycle progression. Thus, to drive proliferation, cells must tolerate DNA damage and suppress the checkpoint response.… read more here.
Keywords: dna damage; stress; damage checkpoint; checkpoint ... See more keywords