Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin (DHM) prophylaxis of NNK-induced lung carcinogenesis.
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DOI: 10.1093/carcin/bgac031
Abstract: Our earlier work demonstrated varying potency of dihydromethysticin (DHM) as the active kava phytochemical for prophylaxis of tobacco carcinogen NNK-induced mouse lung carcinogenesis. Efficacy was dependent on timing of DHM gavage ahead of NNK insult.… read more here.
Keywords: damage; lung carcinogenesis; nnk induced; damage independent ... See more keywords