The effects of altered DNA damage repair genes on mutational processes and immune cell infiltration in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5663
Abstract: Defects in DNA damage repair (DDR) pathways lead to genomic instability and oncogenesis. DDR deficiency is prevalent in esophageal squamous cell carcinoma (ESCC), but the effects of DDR alterations on mutational processes and tumor immune… read more here.
Keywords: cell; cell carcinoma; dna damage; damage repair ... See more keywords
miR‐210‐3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5‐fluorouracil
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23107
Abstract: Chemoresistance is the primary cause of chemotherapy failure. Compelling evidence shows that micro RNAs (miRNAs) contribute to reprogram cancer cells toward a resistant phenotype. We investigate the role of miRNAs in the response to acute… read more here.
Keywords: damage repair; dna damage; treatment; mir 210 ... See more keywords
DNA Damage Repair Inhibitor for Breast Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9620-6_8
Abstract: Cancer has been defined as a genetic disorder caused by the accumulation of genetic alterations, which result from various internal and external DNA damage that is left unrepaired. One of the main characteristics of cancer… read more here.
Keywords: dna damage; inhibitor; damage repair; ddr inhibitors ... See more keywords
An Overview of Chemical and Biological Materials lead to Damage and Repair of Heart Tissue.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular engineering and technology"
DOI: 10.1007/s13239-021-00544-9
Abstract: BACKGROUND Cardiovascular diseases (CVDs) are major causes of mortality in developing countries. One of the challenges during CVDs studies is the creation of a damaged model of the heart. Many injured models of cardiac diseases… read more here.
Keywords: heart; damage repair; biological materials; damage ... See more keywords
Mechanism of cholangiocellular damage and repair during cholestasis.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of hepatology"
DOI: 10.1016/j.aohep.2021.100530
Abstract: The mechanism of damage of the biliary epithelium remains partially unexplored. However, recently many works have offered new evidence regarding the cholangiocytes' damage process, which is the main target in a broad spectrum of pathologies… read more here.
Keywords: damage repair; mechanism cholangiocellular; cholangiocellular damage; damage ... See more keywords
The Helix Twist: Damage and Repair Follows the DNA Minor Groove
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.10.034
Abstract: Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential… read more here.
Keywords: minor groove; helix twist; damage repair;
Biliary Tract Cancer: State of the Art and potential role of DNA Damage Repair.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2018.09.002
Abstract: Biliary tract cancers (BTCs), including cholangiocarcinoma, gallbladder cancer and ampullary cancers, are poor-prognosis malignancies. Most patients are diagnosed with advanced disease, when treatment is limited to palliative chemotherapy. First line chemotherapy is usually administered in… read more here.
Keywords: biliary tract; dna damage; damage repair; potential role ... See more keywords
The role of dePARylation in DNA damage repair and cancer suppression.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.02.002
Abstract: Poly(ADP-ribosyl)ation (PARylation) is a reversible post-translational modification regulating various biological pathways including DNA damage repair (DDR). Rapid turnover of PARylation is critically important for an optimal DNA damage response and maintaining genomic stability. Recent studies… read more here.
Keywords: dna damage; damage repair; deparylation; role ... See more keywords
Understanding the sequence and structural context effects in oxidative DNA damage repair.
Sign Up to like & getrecommendations! Published in 2020 at "DNA repair"
DOI: 10.1016/j.dnarep.2020.102906
Abstract: 8-Oxo-7,8-dihydroguanine (8-oxoG) is the major base damage in the genomic DNA by exposure to reactive oxygen species. Organisms have evolved various DNA repair mechanisms, such as base excision repair (BER) and nucleotide excision repair (NER),… read more here.
Keywords: dna damage; sequence structural; damage repair; oxidative dna ... See more keywords
Association of Germline Variants in Human DNA Damage Repair Genes and Response to Adjuvant Chemotherapy in Resected Pancreatic Ductal Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Surgeons"
DOI: 10.1016/j.jamcollsurg.2020.06.019
Abstract: BACKGROUD The frequency and significance of the germline variants in DNA damage repair genes still need to be elucidated in patients with sporadic pancreatic ductal adenocarcinoma (PDAC). Our purpose was to determine whether germline variants… read more here.
Keywords: damage repair; dna damage; repair genes; germline variants ... See more keywords
A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.02.007
Abstract: Background & Aims Recent evidence has suggested that the intact intestinal epithelial barrier protects our body from a range of immune-mediated diseases. The epithelial layer has an impressive ability to reconstitute and repair upon damage… read more here.
Keywords: damage repair; regeneration; model; damage ... See more keywords