Loss of tRNA methyltransferase 9 and DNA damage response genes in yeast confers sensitivity to aminoglycosides
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14591
Abstract: tRNA methyltransferase 9 (Trm9)‐catalysed tRNA modifications have been shown to translationally enhance the DNA damage response (DDR). Here, we show that Saccharomyces cerevisiae trm9Δ, distinct DNA repair and spindle assembly checkpoint (SAC) mutants are differentially… read more here.
Keywords: dna damage; dna; trna methyltransferase; damage response ... See more keywords
c-Rel dependant Chk2 signalling regulates the DNA damage response limiting hepatocarcinogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32781
Abstract: BACKGROUND AND AIMS Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. c-Rel, an NF-κB transcription factor family subunit is typically pro-tumourigenic, however, it has recently been reported as a tumour suppressor. Here we… read more here.
Keywords: genotoxic injury; dna damage; rel; damage response ... See more keywords
7‐hydroxy‐staurosporine, UCN‐01, induces DNA damage response, and autophagy in human osteosarcoma U2‐OS cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26652
Abstract: Human osteosarcoma (bone cancer) is a highly malignant and the most prevalent bone tumor affecting children. Despite recent advances in the understanding of the molecular mechanism by which anticancer drugs kill osteosarcoma or block its… read more here.
Keywords: damage response; dna damage; human osteosarcoma; osteosarcoma cells ... See more keywords
DNA damage response signaling pathways as important targets for combination therapy and chemotherapy sensitization in osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30721
Abstract: Osteosarcoma (OS) is the most common bone malignancy that occurs most often in young adults, and adolescents with a survival rate of 20% in its advanced stages. Nowadays, increasing the effectiveness of common treatments used… read more here.
Keywords: dna damage; damage response; chemotherapy; damage ... See more keywords
DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7342-8_7
Abstract: In humans, hematopoietic stem cells (HSCs) adopt unique responsive pathways counteracting with the DNA-damaging assaults to weigh the balance between the maintenance of normal stem cell poor for whole-life blood regeneration and the transformation to… read more here.
Keywords: dna damage; damage response; hematopoietic stem; stem ... See more keywords
A novel DNA damage response signature of IDH-mutant grade II and grade III astrocytoma at transcriptional level
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03132-x
Abstract: Purpose The WHO classification for IDH-mutant grade II and grade III astrocytoma may not be as prognostically meaningful as expected. We aimed to develop a novel classification system based on the DNA damage response signature.… read more here.
Keywords: signature; dna damage; damage response; grade ... See more keywords
Prognostic effects of abnormal DNA damage response protein expression in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-019-05128-9
Abstract: PurposeWe aimed to explore the expression of DNA damage response machinery proteins and their integrated prognostic value in different subgroups of breast cancer.MethodsExpression of NBS1, BRCA1, BRCA2, ATM, and p53 was determined by immunohistochemistry in… read more here.
Keywords: damage response; dna damage; response protein; expression ... See more keywords
SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2020 at "Plant Molecular Biology"
DOI: 10.1007/s11103-020-00994-0
Abstract: Plants live in constantly changing and often unfavorable or stressful environments. Environmental changes induce biotic and abiotic stress, which, in turn, may cause genomic DNA damage. Hence, plants simultaneously suffer abiotic/biotic stress and DNA damage.… read more here.
Keywords: dna damage; damage response; crosstalk dna; response ... See more keywords
The DNA damage response pathway in normal hematopoiesis and malignancies
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hematology"
DOI: 10.1007/s12185-017-2300-7
Abstract: In mammalian cells, the DNA damage response (DDR) prevents the replication and propagation of DNA errors to the next generation, thus maintaining genomic stability. At the heart of the DDR are the related signaling kinases… read more here.
Keywords: dna damage; ddr; damage response; dna ... See more keywords
MicroRNAs in DNA Damage Response, Carcinogenesis, and Chemoresistance.
Sign Up to like & getrecommendations! Published in 2017 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2017.03.001
Abstract: In the classical model of tumorigenesis, cancer develops via slowly accumulating mutations that facilitate uncontrolled cell growth and allow cells to escape apoptosis. Oncogenes and tumor suppressor genes regulate the key signaling pathways involved in… read more here.
Keywords: dna damage; damage response; chemoresistance; carcinogenesis ... See more keywords
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response.
Sign Up to like & getrecommendations! Published in 2021 at "DNA repair"
DOI: 10.1016/j.dnarep.2021.103172
Abstract: The transcription-related DNA damage response was visualized on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a small proportion of mature RNA transcripts undergo changes, with significant activation of DNA repair… read more here.
Keywords: dna damage; damage response; response; repair ... See more keywords