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   Articles with "damage response" as a keyword



Loss of tRNA methyltransferase 9 and DNA damage response genes in yeast confers sensitivity to aminoglycosides

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recommendations! Published in 2023 at "FEBS Letters"

DOI: 10.1002/1873-3468.14591

Abstract: tRNA methyltransferase 9 (Trm9)‐catalysed tRNA modifications have been shown to translationally enhance the DNA damage response (DDR). Here, we show that Saccharomyces cerevisiae trm9Δ, distinct DNA repair and spindle assembly checkpoint (SAC) mutants are differentially… read more here.

Keywords: dna damage; dna; trna methyltransferase; damage response ... See more keywords

Acetylated KHSRP impairs DNA‐damage‐response‐related mRNA decay and facilitates prostate cancer tumorigenesis

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13634

Abstract: Androgen‐regulated DNA damage response (DDR) is one of the essential mechanisms in prostate cancer (PCa), a hormone‐sensitive disease. The heterogeneous nuclear ribonucleoprotein K (hnRNPK)‐homology splicing regulatory protein known as far upstream element‐binding protein 2 (KHSRP)… read more here.

Keywords: dna damage; damage response; prostate cancer; pca ... See more keywords

Recent Advances in Anti‐Aging Therapeutic Strategies Targeting DNA Damage Response and Senescence‐Associated Secretory Phenotype‐Linked Signaling Cascade

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recommendations! Published in 2025 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.70046

Abstract: Aging is considered the contributory accumulation of abruptions occurring through cell signaling cascades, which ultimately cause changes in physical functions, cell fate, and damage across all organ systems. DNA damage response (DDR) also occurs through… read more here.

Keywords: dna damage; senescence associated; damage response; damage ... See more keywords

DNA damage response and repair gene mutations predict clinical outcomes in biliary tract cancer

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recommendations! Published in 2025 at "Cancer"

DOI: 10.1002/cncr.35726

Abstract: This study aims to explore the genetic characteristics of biliary tract cancer (BTC), with a particular focus on the impact of DNA damage response and repair (DDR) genes on clinical outcomes. read more here.

Keywords: dna damage; cancer; tract cancer; damage response ... See more keywords

c-Rel dependant Chk2 signalling regulates the DNA damage response limiting hepatocarcinogenesis.

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recommendations! Published in 2022 at "Hepatology"

DOI: 10.1002/hep.32781

Abstract: BACKGROUND AND AIMS Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. c-Rel, an NF-κB transcription factor family subunit is typically pro-tumourigenic, however, it has recently been reported as a tumour suppressor. Here we… read more here.

Keywords: genotoxic injury; dna damage; rel; damage response ... See more keywords
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7‐hydroxy‐staurosporine, UCN‐01, induces DNA damage response, and autophagy in human osteosarcoma U2‐OS cells

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.26652

Abstract: Human osteosarcoma (bone cancer) is a highly malignant and the most prevalent bone tumor affecting children. Despite recent advances in the understanding of the molecular mechanism by which anticancer drugs kill osteosarcoma or block its… read more here.

Keywords: damage response; dna damage; human osteosarcoma; osteosarcoma cells ... See more keywords

DNA damage response signaling pathways as important targets for combination therapy and chemotherapy sensitization in osteosarcoma

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recommendations! Published in 2022 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30721

Abstract: Osteosarcoma (OS) is the most common bone malignancy that occurs most often in young adults, and adolescents with a survival rate of 20% in its advanced stages. Nowadays, increasing the effectiveness of common treatments used… read more here.

Keywords: dna damage; damage response; chemotherapy; damage ... See more keywords

DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells.

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recommendations! Published in 2019 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-981-13-7342-8_7

Abstract: In humans, hematopoietic stem cells (HSCs) adopt unique responsive pathways counteracting with the DNA-damaging assaults to weigh the balance between the maintenance of normal stem cell poor for whole-life blood regeneration and the transformation to… read more here.

Keywords: dna damage; damage response; hematopoietic stem; stem ... See more keywords
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A novel DNA damage response signature of IDH-mutant grade II and grade III astrocytoma at transcriptional level

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recommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-020-03132-x

Abstract: Purpose The WHO classification for IDH-mutant grade II and grade III astrocytoma may not be as prognostically meaningful as expected. We aimed to develop a novel classification system based on the DNA damage response signature.… read more here.

Keywords: signature; dna damage; damage response; grade ... See more keywords
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Prognostic effects of abnormal DNA damage response protein expression in breast cancer

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recommendations! Published in 2019 at "Breast Cancer Research and Treatment"

DOI: 10.1007/s10549-019-05128-9

Abstract: PurposeWe aimed to explore the expression of DNA damage response machinery proteins and their integrated prognostic value in different subgroups of breast cancer.MethodsExpression of NBS1, BRCA1, BRCA2, ATM, and p53 was determined by immunohistochemistry in… read more here.

Keywords: damage response; dna damage; response protein; expression ... See more keywords

SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana

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recommendations! Published in 2020 at "Plant Molecular Biology"

DOI: 10.1007/s11103-020-00994-0

Abstract: Plants live in constantly changing and often unfavorable or stressful environments. Environmental changes induce biotic and abiotic stress, which, in turn, may cause genomic DNA damage. Hence, plants simultaneously suffer abiotic/biotic stress and DNA damage.… read more here.

Keywords: dna damage; damage response; crosstalk dna; response ... See more keywords