Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02688-6
Abstract: T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized patients. Besides… read more here.
Keywords: dna damage; damage responses; damage; cell ... See more keywords
DNA damage responses and p53 in the aging process.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2017-07-746396
Abstract: The genome is constantly attacked by genotoxic insults. DNA damage has long been established as a cause of cancer development through its mutagenic consequences. Conversely, radiation therapy and chemotherapy induce DNA damage to drive cells… read more here.
Keywords: aging process; dna damage; damage responses; damage ... See more keywords