Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14329
Abstract: Damaged lysosomes can be repaired by calcium release‐dependent recruitment of the ESCRT machinery. However, the involvement of annexins, another group of calcium‐responding membrane repair proteins, has not been fully addressed. Here, we show that although… read more here.
Keywords: larger lysosomal; recruited larger; annexins recruited; anxa1 anxa2 ... See more keywords
A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2020.10.004
Abstract: Lysosomes are placed at the center of cellular trafficking and degradative pathways. They also function as a signaling platform for nutrient sensing and metabolic reprogramming. Lysosomes play crucial roles in cellular adaptation in response to… read more here.
Keywords: microscopy; damaged lysosomes; lysosomal membrane; membrane permeabilization ... See more keywords
How cells recognize and remove the perforated lysosome.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2138686
Abstract: Macroautophagy (hereafter autophagy) is a highly conserved intracellular degradation system to maintain cellular homeostasis by degrading cellular components such as misfolded proteins, nonfunctional organelles, pathogens, and cytosol. Conversely, selective autophagy targets and degrades specific cargo,… read more here.
Keywords: remove perforated; cells recognize; recognize remove; perforated lysosome ... See more keywords