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   Articles with "damaged mitochondria" as a keyword



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Neuroglial transmitophagy and Parkinson's disease

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recommendations! Published in 2020 at "Glia"

DOI: 10.1002/glia.23839

Abstract: Mitophagy is essential for the health of dopaminergic neurons because mitochondrial damage is a keystone of Parkinson's disease. The aim of the present work was to study the degradation of mitochondria in the degenerating dopaminergic… read more here.

Keywords: transmitophagy; damaged mitochondria; disease; parkinson disease ... See more keywords
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Friendly mediates membrane depolarization-induced mitophagy in Arabidopsis

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recommendations! Published in 2021 at "Current Biology"

DOI: 10.1016/j.cub.2021.02.034

Abstract: The oxidative environment within the mitochondria makes them particularly vulnerable to proteotoxic stress. To maintain a healthy mitochondrial network, eukaryotes have evolved multi-tiered quality control pathways. If the stress cannot be alleviated, defective mitochondria are… read more here.

Keywords: damaged mitochondria; depolarization induced; friendly mediates; mediates membrane ... See more keywords
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Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia

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recommendations! Published in 2021 at "Redox Biology"

DOI: 10.1016/j.redox.2021.102047

Abstract: The contribution of the Ubiquitin-Proteasome System (UPS) to mitophagy has been largely attributed to the E3 ubiquitin ligase Parkin. Here we show that in response to the oxidative stress associated with hypoxia or the hypoxia… read more here.

Keywords: oxidation damaged; damaged mitochondria; mediated mitophagy; receptor mediated ... See more keywords
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Miro2 supplies a platform for Parkin translocation to damaged mitochondria

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recommendations! Published in 2019 at "Science Bulletin"

DOI: 10.1016/j.scib.2019.04.033

Abstract: PINK1/Parkin-mediated mitophagy is an important process in selective removal of damaged mitochondria, in which translocation of Parkin to damaged mitochondria is recognized as an initiation step. At present, how the damaged mitochondria are selectively recognized… read more here.

Keywords: translocation; damaged mitochondria; supplies platform; parkin translocation ... See more keywords
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Necroptotic debris including damaged mitochondria elicits sepsis-like syndrome during late-phase tularemia

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recommendations! Published in 2017 at "Cell Death Discovery"

DOI: 10.1038/cddiscovery.2017.56

Abstract: Infection with Francisella tularensis ssp. tularensis (Ft) strain SchuS4 causes an often lethal disease known as tularemia in rodents, non-human primates, and humans. Ft subverts host cell death programs to facilitate their exponential replication within… read more here.

Keywords: phase tularemia; damaged mitochondria; infection; sepsis like ... See more keywords
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Actin cages isolate damaged mitochondria during mitophagy

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recommendations! Published in 2018 at "Autophagy"

DOI: 10.1080/15548627.2018.1486152

Abstract: ABSTRACT Mitochondrial homeostasis is maintained by removing dysfunctional, ubiquitinated mitochondria from the network via PRKN-dependent mitophagy. MYO6, a unique myosin that moves towards the minus ends of actin filaments, forms a complex with PRKN and… read more here.

Keywords: mitochondria mitophagy; damaged mitochondria; isolate damaged; actin cages ... See more keywords
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WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2052461

Abstract: ABSTRACT The mammalian Atg18 ortholog WIPI2 is a key regulator of LC3 lipidation to promote autophagosome biogenesis during nonselective macroautophagy, while its functions in selective autophagy such as mitophagy remain largely unexplored. In this study,… read more here.

Keywords: recruitment vcp; wipi2; damaged mitochondria; vcp ... See more keywords
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RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

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recommendations! Published in 2018 at "Science Advances"

DOI: 10.1126/sciadv.aav0443

Abstract: TBK1 phosphorylates RAB7A-S72 to support multiple downstream steps in PARKIN-dependent mitophagy. Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on… read more here.

Keywords: rab7a phosphorylation; damaged mitochondria; rab7a; tbk1 ... See more keywords
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Letting go of damaged mitochondria

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recommendations! Published in 2022 at "Science Signaling"

DOI: 10.1126/scisignal.abq7456

Abstract: Thermogenesis requires that macrophages digest damaged mitochondria released by brown adipocytes. Thermogenesis requires that macrophages digest damaged mitochondria released by brown adipocytes. read more here.

Keywords: damaged mitochondria; letting damaged;
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Oxidative-Damaged Mitochondria Activate GABARAPL1-Induced NLRP3 Inflammasomes in an Autophagic-Exosome Manner after Acute Myocardial Ischemia

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/7958542

Abstract: Objective This study is aimed at identifying the potential diagnostic markers for circulating endothelial cells (CECs) for acute myocardial ischemia (AMI) and exploring the regulatory mechanisms of the selected biomarker in mitochondrial oxidative damage and… read more here.

Keywords: cmecs; cecs; damaged mitochondria; ami ... See more keywords
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Mitochondrial MsrB2 serves as a switch and transducer for mitophagy

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recommendations! Published in 2019 at "EMBO Molecular Medicine"

DOI: 10.15252/emmm.201910409

Abstract: Mitophagy can selectively remove damaged toxic mitochondria, protecting a cell from apoptosis. The molecular spatial–temporal mechanisms governing autophagosomal selection of reactive oxygen species (ROS)‐damaged mitochondria, particularly in a platelet (no genomic DNA for transcriptional regulation),… read more here.

Keywords: serves switch; damaged mitochondria; msrb2 serves; msrb2 ... See more keywords