Genomic Studies Reveal New Aspects of the Biology of DNA Damaging Agents
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700520
Abstract: A flurry of papers has appeared recently to force a rethinking of our understanding of how chemicals, light, and metal complexes damage our genomes. Conventional wisdom was that damaging agents were indiscriminate and it was… read more here.
Keywords: genomic studies; dna damaging; studies reveal; biology ... See more keywords
Cyclic AMP (cAMP) confers drug resistance against DNA damaging agents via PKAIA in CML cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2016.11.043
Abstract: &NA; Cyclic adenosine monophosphate (cAMP) regulates many vital functions such as metabolism, proliferation, differentiation and death. Depending on cell types and stimulators, cAMP could either promote or attenuate cell death. cAMP signal can be transduced… read more here.
Keywords: cml cells; dna damaging; camp; damaging agents ... See more keywords
Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab817
Abstract: Abstract Metallodrugs provide important first-line treatment against various forms of human cancer. To overcome chemotherapeutic resistance and widen treatment possibilities, new agents with improved or alternative modes of action are highly sought after. Here, we… read more here.
Keywords: dna damaging; click chemistry; dna; chemistry ... See more keywords
Abstract CN05-03: Precision therapeutics with DNA-damaging agents
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-cn05-03
Abstract: Precision therapeutics can be defined as the ability to prescribe effective (curative) therapies only to those patients who will respond, while limiting toxicity to normal tissues and minimizing side effects. The paradigm for precision therapeutics… read more here.
Keywords: medicine; dna damaging; response; precision therapeutics ... See more keywords
Abstract A034: USP1 inhibition disrupts DNA repair and potentiates the cytotoxic effects of DNA-damaging agents via persistent DNA damage in cancer cells
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-a034
Abstract: Ubiquitin-specific protease 1 (USP1) is a critical regulator of DNA damage response (DDR) pathways, exerting its function via the deubiquitination of key DNA repair substrates, including FANCD2 and proliferating cell nuclear antigen (PCNA). These deubiquitination… read more here.
Keywords: cancer; inhibition; damaging agents; dna repair ... See more keywords
Abstract 6276: SKL27969, an oral selective PRMT5 inhibitor, sensitizes the effect of DNA-damaging agents in preclinical models of multiple solid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6276
Abstract: Background: Protein arginine methyltransferase 5 (PRMT5) is overexpressed in various human malignancies and induces epigenetic and post-translational changes, which have a significant impact on cell growth, proliferation, apoptosis, and DNA damage repair. SKL27969 is a… read more here.
Keywords: cell; dna; damaging agents; combination ... See more keywords
Abstract 2037: Enhanced chemosensitivity to DNA-damaging agents in human high-grade glioma through 2-DG treatment
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2037
Abstract: Background: Human high-grade gliomas are aggressive brain cancers known for their resistance to treatment. Targeted therapies with single agents have shown limited success, and the presence of tumor heterogeneity complicates treatment. Combining multiple chemotherapeutic agents… read more here.
Keywords: treatment; damaging agents; dna damaging; high grade ... See more keywords